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dc.contributor.authorSafavi-Hemami, H
dc.contributor.authorSiero, WA
dc.contributor.authorKuang, Z
dc.contributor.authorWilliamson, NA
dc.contributor.authorKaras, JA
dc.contributor.authorPage, LR
dc.contributor.authorMacMillan, D
dc.contributor.authorCallaghan, B
dc.contributor.authorKompella, SN
dc.contributor.authorAdams, DJ
dc.contributor.authorNorton, RS
dc.contributor.authorPurcell, AW
dc.date.available2019-11-25T05:02:39Z
dc.date.issued2011
dc.identifierpii: S0021-9258(19)48963-1
dc.identifier.citationSafavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Callaghan, B., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W. (2011). Embryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?. Journal of Biological Chemistry, 286 (25), pp.22546-22557. https://doi.org/10.1074/jbc.M110.217703.
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/11343/233277
dc.description.abstractPredatory marine cone snails (genus Conus) utilize complex venoms mainly composed of small peptide toxins that target voltage- and ligand-gated ion channels in their prey. Although the venoms of a number of cone snail species have been intensively profiled and functionally characterized, nothing is known about the initiation of venom expression at an early developmental stage. Here, we report on the expression of venom mRNA in embryos of Conus victoriae and the identification of novel α- and O-conotoxin sequences. Embryonic toxin mRNA expression is initiated well before differentiation of the venom gland, the organ of venom biosynthesis. Structural and functional studies revealed that the embryonic α-conotoxins exhibit the same basic three-dimensional structure as the most abundant adult toxin but significantly differ in their neurological targets. Based on these findings, we postulate that the venom repertoire of cone snails undergoes ontogenetic changes most likely reflecting differences in the biotic interactions of these animals with their prey, predators, or competitors. To our knowledge, this is the first study to show toxin mRNA transcripts in embryos, a finding that extends our understanding of the early onset of venom expression in animals and may suggest alternative functions of peptide toxins during development.
dc.languageEnglish
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dc.titleEmbryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?
dc.typeJournal Article
dc.identifier.doi10.1074/jbc.M110.217703
melbourne.affiliation.departmentBio21
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentSchool of BioSciences
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.departmentScience Collected Works
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyAffiliates
melbourne.affiliation.facultyScience
melbourne.affiliation.facultyMelbourne Medical School
melbourne.source.titleJournal of Biological Chemistry
melbourne.source.volume286
melbourne.source.issue25
melbourne.source.pages22546-22557
melbourne.identifier.arcDP110101331
melbourne.elementsid338246
melbourne.openaccess.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121399/
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121399
melbourne.openaccess.statusPublished version
melbourne.contributor.authorSAFAVI-HEMAMI, HELENA
melbourne.contributor.authorWilliamson, Nicholas
melbourne.contributor.authorKaras, John
melbourne.contributor.authorMacmillan, David
melbourne.contributor.authorNorton, Raymond
melbourne.contributor.authorPURCELL, ANTHONY
melbourne.contributor.authorCallaghan, Brid
melbourne.contributor.authorSIERO, WILLIAM
dc.identifier.eissn1083-351X
melbourne.identifier.fundernameidAUST RESEARCH COUNCIL, DP110101331
melbourne.accessrightsOpen Access


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