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    What is the optimal distribution of myelin along a single axon?

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    Author
    Walsh, DM; Landman, KA; Hughes, BD
    Date
    2017-09-29
    Source Title
    Neuroscience Letters
    Publisher
    Elsevier
    University of Melbourne Author/s
    Hughes, Barry; Walsh, Darragh; Landman, Kerry
    Affiliation
    School of Mathematics and Statistics
    Metadata
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    Document Type
    Journal Article
    Citations
    Walsh, D. M., Landman, K. A. & Hughes, B. D. (2017). What is the optimal distribution of myelin along a single axon?. Neuroscience Letters, 658, pp.97-101. https://doi.org/10.1016/j.neulet.2017.08.037.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/233854
    DOI
    10.1016/j.neulet.2017.08.037
    ARC Grant code
    ARC/DP140100339
    Abstract
    The myelin sheath that insulates some axons in the central nervous system allows for faster signal conduction. Previously, axons were thought to be either unmyelinated or fully myelinated. Recent experimental work has discovered a new pattern of myelination (intermittent myelination) along axons in the mouse brain, in which long unmyelinated axon segments are followed by myelinated segments of comparable length. We use a computational model to explore how myelin distribution (in particular intermittent myelination) affects conduction velocity. We find that although fully myelinated axons minimize conduction velocity, varying the spatial distribution of a fixed amount of myelin along a partially myelinated axon leads to considerable variation in the conduction velocity for action potentials. Whether sodium ion channel number or sodium ion channel density is held constant as the area of the unmyelinated segments increases has a strong influence on the optimal pattern of myelin and the conduction velocity.

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