University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Is cell migration or proliferation dominant in the formation of linear arrays of oligodendrocytes?

    Thumbnail
    Download
    Accepted version (3.073Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    5
    5
    Author
    Walsh, DM; Roth, PT; Holmes, WR; Landman, KA; Merson, TD; Hughes, BD
    Date
    2016-10-07
    Source Title
    Journal of Theoretical Biology
    Publisher
    Elsevier
    University of Melbourne Author/s
    Landman, Kerry; Merson, Tobias; Hughes, Barry; Walsh, Darragh; ROTH, PHILIPP; HOLMES, WILLIAM
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Anatomy and Neuroscience
    School of Mathematics and Statistics
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Walsh, D. M., Roth, P. T., Holmes, W. R., Landman, K. A., Merson, T. D. & Hughes, B. D. (2016). Is cell migration or proliferation dominant in the formation of linear arrays of oligodendrocytes?. Journal of Theoretical Biology, 406, pp.17-30. https://doi.org/10.1016/j.jtbi.2016.06.028.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/233857
    DOI
    10.1016/j.jtbi.2016.06.028
    ARC Grant code
    ARC/DP140100339
    Abstract
    Oligodendrocytes are the myelin-producing cells of the central nervous system that are responsible for electrically insulating axons to speed the propagation of electrical impulses. A striking feature of oligodendrocyte development within white matter is that the cell bodies of many oligodendrocyte progenitor cells become organised into discrete linear arrays of three or more cells before they differentiate into myelin-producing oligodendrocytes. These linear arrays align parallel to the direction of the axons within white matter tracts and are believed to play an important role in the co-ordination of myelination. Guided by experimental data on the abundance and composition of linear arrays in the corpus callosum of the postnatal mouse brain, we construct discrete and continuous models of linear array generation to specifically investigate the relative influence of cell migration, proliferation, differentiation and death of oligodendroglia upon the genesis of linear arrays during early postnatal development. We demonstrate that only models that incorporate significant cell migration can replicate all of the experimental observations on number of arrays, number of cells in arrays and total cell count of oligodendroglia within a given area of the corpus callosum. These models are also necessary to accurately reflect experimental data on the abundance of linear arrays composed of oligodendrocytes that derive from progenitors of different clonal origins.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • School of Mathematics and Statistics - Research Publications [680]
    • Anatomy and Neuroscience - Research Publications [621]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1052]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors