University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

    Thumbnail
    Download
    Published version (12.18Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    84
    81
    Author
    Mitew, S; Gobius, I; Fenlon, LR; McDougall, SJ; Hawkes, D; Xing, YL; Bujalka, H; Gundlach, AL; Richards, LJ; Kilpatrick, TJ; ...
    Date
    2018-01-22
    Source Title
    NATURE COMMUNICATIONS
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Hawkes, David; Mitew, Stan; Kilpatrick, Trevor; Merson, Tobias; Emery, Ben; Gundlach, Andrew; McDougall, Stuart; Xing, Yao; Bujalka, Helena
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Medicine, Dentistry & Health Sciences
    Anatomy and Neuroscience
    Pharmacology and Therapeutics
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Mitew, S., Gobius, I., Fenlon, L. R., McDougall, S. J., Hawkes, D., Xing, Y. L., Bujalka, H., Gundlach, A. L., Richards, L. J., Kilpatrick, T. J., Merson, T. D. & Emery, B. (2018). Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-017-02719-2.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/234493
    DOI
    10.1038/s41467-017-02719-2
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778130
    Abstract
    Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level is unclear. Here we demonstrate that stimulation of somatosensory axons in the mouse brain increases proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) within the underlying white matter. Stimulated axons display an increased probability of being myelinated compared to neighboring non-stimulated axons, in addition to being ensheathed with thicker myelin. Conversely, attenuating neuronal firing reduces axonal myelination in a selective activity-dependent manner. Our findings reveal that the process of selecting axons for myelination is strongly influenced by the relative activity of individual axons within a population. These observed cellular changes are consistent with the emerging concept that adaptive myelination is a key mechanism for the fine-tuning of neuronal circuitry in the mammalian CNS.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Pharmacology and Therapeutics - Research Publications [387]
    • Anatomy and Neuroscience - Research Publications [621]
    • Medicine, Dentistry & Health Sciences Collected Works - Research Publications [578]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1052]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors