Otolaryngology - Research Publications
Now showing items 1-10 of 47
Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs
Clinically, gentamicin has been used extensively to treat the debilitating symptoms of Meniere's disease and is well known for its vestibulotoxic properties. Until recently, it was widely accepted that the round window ...
Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole
(Wiley Periodicals Inc, 2009)
Fast inhibition alters first spike timing in auditory brainstem neurons
(The American Physiological Society, 2004)
Research directions for future generations of cochlear implants
(Whurr Publishers Ltd, 2004)
Physiological and psychophysical research indicates that improved hearing in noise and music appreciation are likely with cochlear implants, with better reproduction of the fine temporospatial patterns of neural response ...
(American Association for the Advancement of Science (AAAS), 2009)
Electrode materials that facilitate interaction with living cells are crucial for the development of next-generation bionic devices.
Drug delivery to the inner ear
(IOP PUBLISHING LTD, 2012-12-01)
Bionic devices electrically activate neural populations to partially restore lost function. Of fundamental importance is the functional integrity of the targeted neurons. However, in many conditions the ongoing pathology ...
Arousal from sleep in infants is impaired following an infection
(ELSEVIER IRELAND LTD, 2002-02-01)
Numerous studies have postulated a link between recent infection and Sudden Infant Death Syndrome (SIDS). In this study we contrasted arousal responses from sleep in infants on the day of discharge from hospital following ...
Atoh1 gene therapy in the cochlea for hair cell regeneration.
INTRODUCTION: The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory nerve endings, all of which degenerate after hearing loss in mammals. Biological approaches ...
Deletion of the type-1 interferon receptor in APP(SWE)/PS1(Delta E9) mice preserves cognitive function and alters glial phenotype
(BIOMED CENTRAL LTD, 2016-07-11)
A neuro-inflammatory response is evident in Alzheimer's disease (AD), yet the precise mechanisms by which neuro-inflammation influences the progression of Alzheimer's disease (AD) remain poorly understood. Type-1 interferons ...