Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials.
AuthorHan, Y; Lin, Z; Zhou, J; Yun, G; Guo, R; Richardson, JJ; Caruso, F
Source TitleAngew Chem Int Ed Engl
University of Melbourne Author/sCaruso, Francesco
AffiliationChemical and Biomolecular Engineering
Document TypeJournal Article
CitationsHan, Y; Lin, Z; Zhou, J; Yun, G; Guo, R; Richardson, JJ; Caruso, F, Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials., Angew Chem Int Ed Engl, 2020
Access StatusThis item is embargoed and will be available on 2021-03-20
Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins. However, establishing facile and general techniques for assembling proteins into nanomaterials is challenging owing to the complex physicochemical nature and potential denaturation of proteins. Here a simple, versatile strategy is introduced to fabricate functional protein assemblies through the interfacial assembly of proteins (>10 studied herein) and polyphenols (e.g., tannic acid) on various substrates (organic, inorganic, and biological). The dominant interactions (hydrogen bonding, hydrophobic and ionic interactions) between the proteins and tannic acid are elucidated-most proteins undergo multiple noncovalent-stabilizing interactions with polyphenols, which can be used to engineer responsiveness into the assemblies. As demonstrated, the proteins retain their structure and function within the assemblies, thereby enabling their use in various applications (e.g., catalysis, fluorescent imaging, and cell targeting).
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