Now showing items 1-3 of 1656

    • A quantitative framework for lymphocyte fate decisions 

      Horton, Miles Benjamin (2021)
      During an adaptive immune response activated B and T lymphocytes undergo rapid clonal expansion and generate extensive cellular heterogeneity. How lymphocytes guarantee the emergence of functional diversity amongst responding ...
    • Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells 

      Rigau, M; Ostrouska, S; Fulford, TS; Johnson, DN; Woods, K; Ruan, Z; McWilliam, HEG; Hudson, C; Tutuka, C; Wheatley, AK; ... (American Association for the Advancement of Science, 2020-02-07)
      Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) that respond to phosphoantigens (pAgs) produced by cellular pathogens and overexpressed by ...
    • Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens 

      McWilliam, HEG; Mak, JYW; Awad, W; Zorkau, M; Cruz-Gomez, S; Lim, HJ; Yan, Y; Wormald, S; Dagley, LF; Eckle, SBG; ... (NATL ACAD SCIENCES, 2020-10-06)
      The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2 synthesis to activate mucosal-associated invariant T (MAIT) cells. Key aspects of this ...