Medical Biology: Recent submissions
Now showing items 1-3 of 1656
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A quantitative framework for lymphocyte fate decisions
(2021)During an adaptive immune response activated B and T lymphocytes undergo rapid clonal expansion and generate extensive cellular heterogeneity. How lymphocytes guarantee the emergence of functional diversity amongst responding ... -
Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells
(American Association for the Advancement of Science, 2020-02-07)Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) that respond to phosphoantigens (pAgs) produced by cellular pathogens and overexpressed by ... -
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
(NATL ACAD SCIENCES, 2020-10-06)The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2 synthesis to activate mucosal-associated invariant T (MAIT) cells. Key aspects of this ...