Medical Biology - Research Publications
Now showing items 1-10 of 100
Elevated labile Cu is associated with oxidative pathology in Alzheimer's disease.
Oxidative stress is implicated in Alzheimer disease (AD) pathogenesis, for which evidence indicates that radical species are generated by the redox-active biometal Cu. The contribution of labile Cu to the oxidative stress ...
A biosensor of Src family kinase conformation by exposable tetracysteine useful for cell-based screening
(American Chemical Society (ACS), 2014)
We developed a new approach to distinguish distinct protein conformations in live cells. The method, exposable tetracysteine (XTC), involved placing an engineered tetracysteine motif into a target protein that has conditional ...
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation
(National Academy of Sciences, 2014)
Thrombopoietin (TPO) acting via its receptor, the cellular homologue of the myeloproliferative leukemia virus oncogene (Mpl), is the major cytokine regulator of platelet number. To precisely define the role of specific ...
Thrombotic thrombocytopenic purpura is associated with a high relapse rate after plasma exchange: a single-centre experience
(Blackwell Snergy, 2008)
Background: Thrombotic thrombocytopenic purpura (TTP) is a rare condition characterized by microangiopathic haemolytic anaemia, thrombocytopenia, renal and/or neurological dysfunction secondary to microvascular or macrovascular ...
Cytomegalovirus DNAemia and disease: natural history and management in settings other than allogeneic stem cell transplantation
(Ferrata Storti Foundation, 2005-12)
Background and Objectives. Despite increasing intensity and profound immunosuppressionassociated with newer therapies for hematologic malignancies, little information exists regarding cytomegalovirus (CMV) reactivation in ...
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
Many cytokines exert their biological effect through members of the hemopoietin receptor family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from human hemopoietic cell cDNA libraries various ...