Medical Biology - Theses
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The molecular epidemiology of Plasmodium spp. in Solomon Islands
Malaria is a major global disease burden with significant mortality rates amongst young children. The renewed commitment to eradicate malaria along with intensified control efforts has drastically reduced malaria transmission ...
Investigation of the mitochondrial translocase of the outer membrane (TOM) of Drosophila melanogaster
The macromolecular protein translocation machinery of the outer mitochondrial membrane, TOM, mediates the import of nuclear-encoded mitochondria-bound precursor proteins. Moreover, a demonstrated role in importing pathogenic ...
Novel genes and mechanisms in monogenic autoinflammatory disorders
Monogenic autoinflammatory disorders are a heterogeneous group of rare conditions characterised by innate immune dysregulation. Patients often present early in life with recurrent fevers and features of systemic inflammation ...
Investigation into the regulatory mechanisms of the NOD2 signalling pathway
Nucleotide-binding oligomerisation domain-containing (NOD) receptor 2 (NOD2) is a critical intracellular sentinel for Gram-positive and Gram-negative bacteria through the recognition of the bacterial cell wall component ...
Targeting regulators of natural killer cell homeostasis in cancer immunotherapy
The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory receptors and from cytokines such as IL-15. The ability to recognise tumour cells in ...
The pro-apoptotic proteins BAK and BAX: activation and apoptotic pore formation
The BCL-2 family proteins BAK and BAX are the executioners of intrinsic apoptosis. Following activation by BH3-only proteins, they undergo structural rearrangements that promote their homo-dimerization and subsequent ...
Multiple endocrine neoplasia type 2B: modelling the disease in human cells and avian embryos
Paediatric cancer initiation is difficult to study because the early stages are often prenatal. Patient cells at the time of detection already have complex genetic (including epigenetic) changes, and the cancer cell ...
Regulation of BH3-only proteins by IKK, downstream of beta-common receptor signalling
Apoptosis is a tightly regulated process and is responsible for maintaining tissue homeostasis, controlling cell numbers and the elimination of damaged or unwanted cells. Intrinsic apoptosis, also known as the mitochondrial ...
Investigating the structure and function of transmembrane domains in MARCH e3 ligases and single-span receptors
Single-span receptors play essential roles in mediating communication amongst cells of the haematopoietic system, and their single transmembrane (TM) a-helices are often important determinants for receptor function. They ...
Characterisation of mice deficient for the pro-survival BCL-2 family member A1/BFL-1
Apoptosis is important for the development and maintenance of a healthy immune system. The intrinsic apoptotic pathway is regulated by the BCL-2 family of proteins, which consists of both pro-survival and pro-apoptotic ...