Medical Biology - Theses
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Understanding the role of MYCN in ovarian cancer to underpin treatment strategies
Ovarian cancer (OC) is a heterogeneous disease composed of multiple distinct molecular and clinical subtypes. Women with OC, in particular, high grade serous ovarian cancer (HGSOC), face a formidable challenge as fatal ...
The roles of Hhex and Ikzf1 in murine NK cell biology
Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-infected cells. NK cells originate from haematopoietic stem cells in the bone ...
Defining programs of cell death that can be harnessed to impact on outcomes of chronic viral infection
Pathogens causing chronic infections have successfully evolved mechanisms to subvert host immunity. Excessive and inappropriate inflammation together with attrition of repeatedly overstimulated high affinity T cells leads ...
Insights into mechanisms of resistance to apoptosis in Epstein-Barr virus-associated T and NK cell lymphomas
Ectopic Epstein-Barr virus (EBV) infection of T or NK cells is associated with several aggressive diseases including extra-nodal NK/T cell lymphoma (ENKTL) and chronic active EBV (CAEBV). Resistance to standard chemotherapy ...
Investigating circulating miRNA markers of response to triple DMARD therapy, and profiling synovial fluid extracellular vesicles in patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs due to an abnormal immune response which perpetuates inflammation in affected joints and can lead to the irreversible destruction of articular cartilage ...
Molecular mechanisms of thymic tolerance induction and recovery from involution
Thymic epithelial cells (TECs) are vital for the formation of the thymic microenvironment and the differentiation of T cells. This process involves a series of interactions between TECs and thymocytes that govern T cell ...
The Genomics of Oral and Oropharyngeal Squamous Cell Carcinoma
Head and neck squamous carcinomas (HNSCCs) are a diverse group of squamous cell cancers in the upper aerodigestive tract. Whilst tobacco, alcohol, and the human papilloma virus (HPV) have been implicated in HNSCC oncogenesis, ...
Regulation of human T-cell function by short chain fatty acids
Short chain fatty acids (SCFAs) are important bacterial metabolites produced by the fermentation of complex carbohydrates in the large gut. Luminal SCFAs are act locally to maintain the integrity of the gut epithelium and ...
Inhibitor of APoptosis proteins (IAPs) and SHARPIN regulate the immune response in the skin to limit inflammation and maintain homeostasis
The skin is a remarkable organ, a barricade between our vulnerable insides and a constantly changing environment full of physical, chemical, and biological aggressors. Maintenance of barrier integrity, immune surveillance, ...
Cytokine signalling in haematopoietic cells
Cytokine receptor signalling is essential for cell survival, proliferation and subsequent differentiation of haematopoietic stem cells (HSCs). Cytokines control development of haematopoietic progenitors into cells of the ...