Medical Biology - Theses
Now showing items 1-10 of 202
Investigating the molecular basis of human NLRP1 inflammasome activation
Cytosolic sensor proteins like NLRP1 (NOD-like receptor containing a pyrin domain 1) play a fundamental role in mediating innate immunity. Upon activation they form signalling hubs that recruit the adaptor protein ASC ...
Identify new regulators of TNFR1-induced necroptotic pathway
Acute Myeloid Leukaemia (AML) is a vastly heterogeneous blood disorder with a poor prognosis for patients older than 65. Our group has been focused on developing new treatments for AML to replace the standard intensive ...
Identifying Plasmodium vivax encoded proteins that may prevent host cell death during liver development
Malaria is a major global health problem and a leading cause of death worldwide. The mechanism behind some parts of the parasite life cycle are still obscure, especially the liver stage which is essential for parasite ...
Measuring B-lymphocyte responses in human health and primary immunodeficiency
Production of high-quality, specific antibody is essential for lifelong protection against pathogens. Generation of antibodies is the end result of a complex and highly regulated process of B cell development and signalling. ...
Structural and functional characterisation of the molecular assembly of two pseudokinase scaffolds
The human pseudokinase SgK269, and its structurally related homologue SgK223, are oncogenic interacting scaffolds that promote the assembly of specific tyrosine kinase signalling pathways. SgK223 and SgK269, as well as the ...
Advancing BH3 mimetics to treat cancers
The evasion of apoptosis, one of the hallmarks of cancer, is observed in many cancers. This can also impair the efficacy of many conventional chemotherapies. The BCL2 protein family is the central regulator of the intrinsic ...
Integration of ‘omics data dissects genetic and metabolic drivers of Macular Telangiectasia Type II
Macular telangiectasia type 2 (MacTel), is a rare degenerative eye disease. In this thesis, we will explore and analyse MacTel ‘omics data including genomics, metabolomics and phenomics data to discover MacTel causal drivers ...
Steady-state and emergency dendritic cell development at a clonal level
Recent clonal fate and single cell RNA-sequencing studies demonstrate that significant lineage imprinting is already in place within individual haematopoietic stem and progenitor cells (HSPCs). Dendritic cells (DCs) represent ...
Screening for breath: identifying Aurkb as a novel regulator of lung development
The development of the lung is a highly regulated and complex process that is not fully characterised. Although there have been many studies into the development of the lung many of the mechanisms regulating lung organogenesis ...
Modelling the multistep pathogenesis of T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive T-cell malignancy that is frequently caused by the overexpression of oncogenic transcription factors. Like many cancers, T-ALL is a heterogeneous disease, with ...