Medical Biology - Theses
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Screening for breath: identifying Aurkb as a novel regulator of lung development
The development of the lung is a highly regulated and complex process that is not fully characterised. Although there have been many studies into the development of the lung many of the mechanisms regulating lung organogenesis ...
Modelling the multistep pathogenesis of T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive T-cell malignancy that is frequently caused by the overexpression of oncogenic transcription factors. Like many cancers, T-ALL is a heterogeneous disease, with ...
New tools for deciphering the roles of tryptophan C-mannosylation
Tryptophan C-mannosylation involves the covalent and irreversible attachment of α-D-mannose onto the C2 carbon of the indole ring of tryptophan forming an unusual C-glycosidic bond that is far more stable than an N- or ...
Mechanisms of angiogenesis in development and disease
The expansion of blood vessel networks by angiogenesis is critical for matching blood supply to the metabolic demands of growing tissues. In adult tissues, blood vessels and the endothelial cells (ECs) that make them ...
The Transcription Factor T-bet in the Control of Germinal Centre Dynamics in Malaria
With reductions in the global malaria burden stalled, this preventable and curable infectious disease caused by the Plasmodium parasites, remains a public health challenge that affects the world’s most vulnerable populations. ...
Exploring Plasmodium vivax transmission dynamics and population genetics through genetics and genomics
Globally, malaria remains one of the most life-threatening and highest burden infectious diseases. Amongst the six Plasmodium species that cause malaria in humans, Plasmodium vivax and Plasmodium falciparum are the ...
Understanding the role of MYCN in ovarian cancer to underpin treatment strategies
Ovarian cancer (OC) is a heterogeneous disease composed of multiple distinct molecular and clinical subtypes. Women with OC, in particular, high grade serous ovarian cancer (HGSOC), face a formidable challenge as fatal ...
The roles of Hhex and Ikzf1 in murine NK cell biology
Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-infected cells. NK cells originate from haematopoietic stem cells in the bone ...
Defining programs of cell death that can be harnessed to impact on outcomes of chronic viral infection
Pathogens causing chronic infections have successfully evolved mechanisms to subvert host immunity. Excessive and inappropriate inflammation together with attrition of repeatedly overstimulated high affinity T cells leads ...
Insights into mechanisms of resistance to apoptosis in Epstein-Barr virus-associated T and NK cell lymphomas
Ectopic Epstein-Barr virus (EBV) infection of T or NK cells is associated with several aggressive diseases including extra-nodal NK/T cell lymphoma (ENKTL) and chronic active EBV (CAEBV). Resistance to standard chemotherapy ...