Short chain fatty acids (SCFAs) are important bacterial metabolites produced by the fermentation of complex carbohydrates in the large gut. Luminal SCFAs are act locally to maintain the integrity of the gut epithelium and ...

The skin is a remarkable organ, a barricade between our vulnerable insides and a constantly changing environment full of physical, chemical, and biological aggressors. Maintenance of barrier integrity, immune surveillance, ...

Cytokine receptor signalling is essential for cell survival, proliferation and subsequent differentiation of haematopoietic stem cells (HSCs). Cytokines control development of haematopoietic progenitors into cells of the ...

The malaria parasite exports a large repertoire of proteins into the host erythrocyte during blood stage infection. This essential process of host cell remodelling is largely dependent upon the cleavage of a conserved amino ...

Cellular processes important for haematopoiesis are frequently perturbed in malignant cells. Accordingly, healthy immature progenitor cells and malignant cancer cells often share certain properties, e.g. rapid proliferation ...

The cyto-protective molecule Parkin is a criticial player in autosomal-recessive Parkinson’s disease, with approximately half of all patients with this condition carrying a mutant allele of PRKN/PARK2. The E3 ubiquitin ...

The discovery that RNA not only functions as an intermediate between a gene and a protein but also possesses regulatory functions has brought significant interest in its potential role in development and disease, and it ...

Plasma cells are a critical component of the adaptive immune system being responsible for the production of large amounts of antibodies which can bind and remove pathogens. Plasma cell formation and function is regulated ...

Single-cell RNA sequencing (scRNA-seq) technology enables high-throughput transcriptome profiling at single-cell resolution, providing researchers with an unprecedented opportunity for dissecting heterogeneous biological ...

Gastric cancer is the fifth most common malignancy and third highest cause of cancer-related deaths worldwide. Although defects in several cell-signalling pathways have been implicated in the initiation and progression of ...