Medical Biology - Theses
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Regulation of human T-cell function by short chain fatty acids
Short chain fatty acids (SCFAs) are important bacterial metabolites produced by the fermentation of complex carbohydrates in the large gut. Luminal SCFAs are act locally to maintain the integrity of the gut epithelium and ...
Inhibitor of APoptosis proteins (IAPs) and SHARPIN regulate the immune response in the skin to limit inflammation and maintain homeostasis
The skin is a remarkable organ, a barricade between our vulnerable insides and a constantly changing environment full of physical, chemical, and biological aggressors. Maintenance of barrier integrity, immune surveillance, ...
Cytokine signalling in haematopoietic cells
Cytokine receptor signalling is essential for cell survival, proliferation and subsequent differentiation of haematopoietic stem cells (HSCs). Cytokines control development of haematopoietic progenitors into cells of the ...
Understanding the mechanisms of protein export in Plasmodium berghei liver infection
The malaria parasite exports a large repertoire of proteins into the host erythrocyte during blood stage infection. This essential process of host cell remodelling is largely dependent upon the cleavage of a conserved amino ...
The role of HECTD1 and MCL-1 in the regulation of normal and malignant haematopoiesis
Cellular processes important for haematopoiesis are frequently perturbed in malignant cells. Accordingly, healthy immature progenitor cells and malignant cancer cells often share certain properties, e.g. rapid proliferation ...
Regulation of the apoptotic machinery by the E3 ubiquitin ligase Parkin
The cyto-protective molecule Parkin is a criticial player in autosomal-recessive Parkinson’s disease, with approximately half of all patients with this condition carrying a mutant allele of PRKN/PARK2. The E3 ubiquitin ...
Understanding RNA transport via exosomes and SIDT2
The discovery that RNA not only functions as an intermediate between a gene and a protein but also possesses regulatory functions has brought significant interest in its potential role in development and disease, and it ...
The functional role of interferon regulatory factor 4 in plasma cells
Plasma cells are a critical component of the adaptive immune system being responsible for the production of large amounts of antibodies which can bind and remove pathogens. Plasma cell formation and function is regulated ...
Improving differential expression analysis of single-cell RNA-seq data: method and application
Single-cell RNA sequencing (scRNA-seq) technology enables high-throughput transcriptome profiling at single-cell resolution, providing researchers with an unprecedented opportunity for dissecting heterogeneous biological ...
Understanding the role of pro-inflammatory cytokines in gastric cancer
Gastric cancer is the fifth most common malignancy and third highest cause of cancer-related deaths worldwide. Although defects in several cell-signalling pathways have been implicated in the initiation and progression of ...