Medical Biology - Theses
Now showing items 1-10 of 174
The functional role of interferon regulatory factor 4 in plasma cells
Plasma cells are a critical component of the adaptive immune system being responsible for the production of large amounts of antibodies which can bind and remove pathogens. Plasma cell formation and function is regulated ...
Improving differential expression analysis of single-cell RNA-seq data: method and application
Single-cell RNA sequencing (scRNA-seq) technology enables high-throughput transcriptome profiling at single-cell resolution, providing researchers with an unprecedented opportunity for dissecting heterogeneous biological ...
Understanding the role of pro-inflammatory cytokines in gastric cancer
Gastric cancer is the fifth most common malignancy and third highest cause of cancer-related deaths worldwide. Although defects in several cell-signalling pathways have been implicated in the initiation and progression of ...
Identification and characterisation of monoclonal antibodies against malaria
Plasmodium falciparum and Plasmodium vivax are responsible for the majority of malaria-related deaths globally. The clinical symptoms of malaria are caused by the blood-stage infection. Malaria parasites invade erythrocytes ...
Analysing the impact of the absence of CARD containing caspases on different forms of cell death
Cell death is an important process during embryogenesis as well as tissue homeostasis in the adult. Apoptosis, pyroptosis and necroptosis are three of the major programmed cell death pathways. Dysregulation of either of ...
The role of transcription factors in multiple myeloma
Multiple myeloma (MM) is an incurable cancer of antibody secreting plasma cells. Approximately 1700 people are diagnosed and 900 people die from MM in Australia annually. During my PhD, I have interrogated the function of ...
Association between antibody responses to blood stage parasitic antigens and protection from Plasmodium falciparum and Plasmodium vivax Malaria in Timika, Indonesia
Malaria is a major health problem causing over 212 million clinical cases every year around the world. In Indonesia, Timika is one of the highest malaria-endemic areas with a high annual parasite incidence (876 per 1,000 ...
The role of PHF6 in haematopoiesis and tumour suppression
Investigating the role of the inner helix bundle crossing during KIR channel gating
Control over potassium (K+) levels is essential to normal tissue homeostasis and a number of physiological processes such as electrolyte balance, cell signalling and cellular electrical activity. Potassium channels mediate ...
Dissecting the role of TNF signalling in Mycobacterium tuberculosis disease pathogenesis to identify novel therapeutic targets
Mycobacterium tuberculosis (Mtb) is a formidable public health challenge, with a global epidemic, fuelled partly by rampant antibiotic resistance, that has the medical community grappling with more infected individuals ...