Plasma cells are a critical component of the adaptive immune system being responsible for the production of large amounts of antibodies which can bind and remove pathogens. Plasma cell formation and function is regulated ...

Single-cell RNA sequencing (scRNA-seq) technology enables high-throughput transcriptome profiling at single-cell resolution, providing researchers with an unprecedented opportunity for dissecting heterogeneous biological ...

Gastric cancer is the fifth most common malignancy and third highest cause of cancer-related deaths worldwide. Although defects in several cell-signalling pathways have been implicated in the initiation and progression of ...

Plasmodium falciparum and Plasmodium vivax are responsible for the majority of malaria-related deaths globally. The clinical symptoms of malaria are caused by the blood-stage infection. Malaria parasites invade erythrocytes ...

Cell death is an important process during embryogenesis as well as tissue homeostasis in the adult. Apoptosis, pyroptosis and necroptosis are three of the major programmed cell death pathways. Dysregulation of either of ...

Multiple myeloma (MM) is an incurable cancer of antibody secreting plasma cells. Approximately 1700 people are diagnosed and 900 people die from MM in Australia annually. During my PhD, I have interrogated the function of ...

Malaria is a major health problem causing over 212 million clinical cases every year around the world. In Indonesia, Timika is one of the highest malaria-endemic areas with a high annual parasite incidence (876 per 1,000 ...

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Control over potassium (K+) levels is essential to normal tissue homeostasis and a number of physiological processes such as electrolyte balance, cell signalling and cellular electrical activity. Potassium channels mediate ...

Mycobacterium tuberculosis (Mtb) is a formidable public health challenge, with a global epidemic, fuelled partly by rampant antibiotic resistance, that has the medical community grappling with more infected individuals ...