Medical Biology - Theses
Now showing items 1-10 of 199
Measuring B-lymphocyte responses in human health and primary immunodeficiency
Production of high-quality, specific antibody is essential for lifelong protection against pathogens. Generation of antibodies is the end result of a complex and highly regulated process of B cell development and signalling. ...
Structural and functional characterisation of the molecular assembly of two pseudokinase scaffolds
The human pseudokinase SgK269, and its structurally related homologue SgK223, are oncogenic interacting scaffolds that promote the assembly of specific tyrosine kinase signalling pathways. SgK223 and SgK269, as well as the ...
Advancing BH3 mimetics to treat cancers
The evasion of apoptosis, one of the hallmarks of cancer, is observed in many cancers. This can also impair the efficacy of many conventional chemotherapies. The BCL2 protein family is the central regulator of the intrinsic ...
Integration of ‘omics data dissects genetic and metabolic drivers of Macular Telangiectasia Type II
Macular telangiectasia type 2 (MacTel), is a rare degenerative eye disease. In this thesis, we will explore and analyse MacTel ‘omics data including genomics, metabolomics and phenomics data to discover MacTel causal drivers ...
Steady-state and emergency dendritic cell development at a clonal level
Recent clonal fate and single cell RNA-sequencing studies demonstrate that significant lineage imprinting is already in place within individual haematopoietic stem and progenitor cells (HSPCs). Dendritic cells (DCs) represent ...
Screening for breath: identifying Aurkb as a novel regulator of lung development
The development of the lung is a highly regulated and complex process that is not fully characterised. Although there have been many studies into the development of the lung many of the mechanisms regulating lung organogenesis ...
Modelling the multistep pathogenesis of T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive T-cell malignancy that is frequently caused by the overexpression of oncogenic transcription factors. Like many cancers, T-ALL is a heterogeneous disease, with ...
New tools for deciphering the roles of tryptophan C-mannosylation
Tryptophan C-mannosylation involves the covalent and irreversible attachment of α-D-mannose onto the C2 carbon of the indole ring of tryptophan forming an unusual C-glycosidic bond that is far more stable than an N- or ...
Mechanisms of angiogenesis in development and disease
The expansion of blood vessel networks by angiogenesis is critical for matching blood supply to the metabolic demands of growing tissues. In adult tissues, blood vessels and the endothelial cells (ECs) that make them ...
The Transcription Factor T-bet in the Control of Germinal Centre Dynamics in Malaria
With reductions in the global malaria burden stalled, this preventable and curable infectious disease caused by the Plasmodium parasites, remains a public health challenge that affects the world’s most vulnerable populations. ...