Ovarian cancer (OC) is a heterogeneous disease composed of multiple distinct molecular and clinical subtypes. Women with OC, in particular, high grade serous ovarian cancer (HGSOC), face a formidable challenge as fatal ...

Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-infected cells. NK cells originate from haematopoietic stem cells in the bone ...

Pathogens causing chronic infections have successfully evolved mechanisms to subvert host immunity. Excessive and inappropriate inflammation together with attrition of repeatedly overstimulated high affinity T cells leads ...

Ectopic Epstein-Barr virus (EBV) infection of T or NK cells is associated with several aggressive diseases including extra-nodal NK/T cell lymphoma (ENKTL) and chronic active EBV (CAEBV). Resistance to standard chemotherapy ...

Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs due to an abnormal immune response which perpetuates inflammation in affected joints and can lead to the irreversible destruction of articular cartilage ...

Thymic epithelial cells (TECs) are vital for the formation of the thymic microenvironment and the differentiation of T cells. This process involves a series of interactions between TECs and thymocytes that govern T cell ...

Head and neck squamous carcinomas (HNSCCs) are a diverse group of squamous cell cancers in the upper aerodigestive tract. Whilst tobacco, alcohol, and the human papilloma virus (HPV) have been implicated in HNSCC oncogenesis, ...

Short chain fatty acids (SCFAs) are important bacterial metabolites produced by the fermentation of complex carbohydrates in the large gut. Luminal SCFAs are act locally to maintain the integrity of the gut epithelium and ...

The skin is a remarkable organ, a barricade between our vulnerable insides and a constantly changing environment full of physical, chemical, and biological aggressors. Maintenance of barrier integrity, immune surveillance, ...

Cytokine receptor signalling is essential for cell survival, proliferation and subsequent differentiation of haematopoietic stem cells (HSCs). Cytokines control development of haematopoietic progenitors into cells of the ...