The cyto-protective molecule Parkin is a criticial player in autosomal-recessive Parkinson’s disease, with approximately half of all patients with this condition carrying a mutant allele of PRKN/PARK2. The E3 ubiquitin ...

The discovery that RNA not only functions as an intermediate between a gene and a protein but also possesses regulatory functions has brought significant interest in its potential role in development and disease, and it ...

Plasma cells are a critical component of the adaptive immune system being responsible for the production of large amounts of antibodies which can bind and remove pathogens. Plasma cell formation and function is regulated ...

Single-cell RNA sequencing (scRNA-seq) technology enables high-throughput transcriptome profiling at single-cell resolution, providing researchers with an unprecedented opportunity for dissecting heterogeneous biological ...

Gastric cancer is the fifth most common malignancy and third highest cause of cancer-related deaths worldwide. Although defects in several cell-signalling pathways have been implicated in the initiation and progression of ...

Plasmodium falciparum and Plasmodium vivax are responsible for the majority of malaria-related deaths globally. The clinical symptoms of malaria are caused by the blood-stage infection. Malaria parasites invade erythrocytes ...

Cell death is an important process during embryogenesis as well as tissue homeostasis in the adult. Apoptosis, pyroptosis and necroptosis are three of the major programmed cell death pathways. Dysregulation of either of ...

Multiple myeloma (MM) is an incurable cancer of antibody secreting plasma cells. Approximately 1700 people are diagnosed and 900 people die from MM in Australia annually. During my PhD, I have interrogated the function of ...

Malaria is a major health problem causing over 212 million clinical cases every year around the world. In Indonesia, Timika is one of the highest malaria-endemic areas with a high annual parasite incidence (876 per 1,000 ...

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