Show simple item record

dc.contributor.authorBaten, AKMA
dc.contributor.authorHalgamuge, SK
dc.contributor.authorChang, BCH
dc.date.accessioned2020-05-21T03:54:21Z
dc.date.available2020-05-21T03:54:21Z
dc.date.issued2008-12-12
dc.identifierpii: 1471-2105-9-S12-S8
dc.identifier.citationBaten, A. K. M. A., Halgamuge, S. K. & Chang, B. C. H. (2008). Fast splice site detection using information content and feature reduction. BMC Bioinformatics, 9 (S12), pp.1-12. https://doi.org/10.1186/1471-2105-9-S12-S8.
dc.identifier.issn1471-2105
dc.identifier.urihttp://hdl.handle.net/11343/239167
dc.description.abstractBACKGROUND: Accurate identification of splice sites in DNA sequences plays a key role in the prediction of gene structure in eukaryotes. Already many computational methods have been proposed for the detection of splice sites and some of them showed high prediction accuracy. However, most of these methods are limited in terms of their long computation time when applied to whole genome sequence data. RESULTS: In this paper we propose a hybrid algorithm which combines several effective and informative input features with the state of the art support vector machine (SVM). To obtain the input features we employ information content method based on Shannon's information theory, Shapiro's score scheme, and Markovian probabilities. We also use a feature elimination scheme to reduce the less informative features from the input data. CONCLUSION: In this study we propose a new feature based splice site detection method that shows improved acceptor and donor splice site detection in DNA sequences when the performance is compared with various state of the art and well known methods.
dc.languageeng
dc.publisherBioMed Central
dc.titleFast splice site detection using information content and feature reduction
dc.typeJournal Article
dc.identifier.doi10.1186/1471-2105-9-S12-S8
melbourne.affiliation.departmentMechanical Engineering
melbourne.source.titleBMC Bioinformatics
melbourne.source.volume9
melbourne.source.issueS12
melbourne.source.pages1-12
dc.rights.licenseCC BY
melbourne.elementsid377765
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638148
melbourne.contributor.authorHalgamuge, Saman
melbourne.contributor.authorBATEN, A K M ABDUL
dc.identifier.eissn1471-2105
melbourne.conference.locationEngland
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record