Show simple item record

dc.contributor.authorYu, L
dc.contributor.authorLacorcia, L
dc.contributor.authorFinch, S
dc.contributor.authorJohnstone, T
dc.date.accessioned2020-06-09T12:15:20Z
dc.date.available2020-06-09T12:15:20Z
dc.date.issued2020
dc.identifierjvim.15831
dc.identifier.citationYu, L., Lacorcia, L., Finch, S. & Johnstone, T. (2020). Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine. Journal of Veterinary Internal Medicine, 34 (4), https://doi.org/10.1111/jvim.15831.
dc.identifier.issn0891-6640
dc.identifier.urihttp://hdl.handle.net/11343/240445
dc.description.abstractBackground: Serum symmetric dimethylarginine (SDMA) is a sensitive renal biomarker for detecting early chronic kidney disease (CKD) in nonhyperthyroid cats, but knowledge regarding its performance in hyperthyroid cats remains limited. Objectives: To determine the relationship between serum SDMA, creatinine and total thyroxine (TT4) concentrations in hyperthyroid cats before (T0) and 3 months after (T1) receiving a PO fixed dose of radioiodine. Animals: Eighty client‐owned hyperthyroid cats. Methods: Prospective cohort study. Serum TT4, and SDMA, creatinine concentrations, and urine specific gravity were measured at T0 and T1. Nonparametric tests were used to determine the relationship among SDMA, and creatinine and TT4 concentrations. Agreement between SDMA and creatinine regarding CKD staging at both time points was assessed using Goodman and Kruskal's gamma statistic. Results: Mean serum SDMA concentration increased after treatment of hyperthyroidism. However, 21 of 75 cats experienced a decrease in SDMA between T0 and T1, whereas creatinine decreased in only 2 cats. A moderate correlation between SDMA and creatinine was seen at T1 (r = 0.53; P < .001) but not at T0 (r = 0.13; P = .25). Where assessable at T1, poor agreement was observed between SDMA and creatinine and CKD stage (Goodman and Kruskal's gamma 0.20; P = .29). Conclusions and clinical importance: Discordant outcomes between SDMA and creatinine after radioiodine treatment in cats with hyperthyroidism suggest extrarenal factors may interfere with the reliability of SDMA to adequately reflect renal function. As a result, SDMA should not be interpreted in isolation in hyperthyroid cats treated with radioiodine.
dc.languageen
dc.publisherWiley
dc.titleAssessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine
dc.typeJournal Article
dc.identifier.doi10.1111/jvim.15831
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.affiliation.departmentMelbourne Veterinary School
melbourne.affiliation.departmentVeterinary Clinical Sciences
melbourne.source.titleJournal of Veterinary Internal Medicine
melbourne.source.volume34
melbourne.source.issue4
dc.rights.licenseCC BY
melbourne.elementsid1451919
melbourne.contributor.authorJohnstone, Thurid
melbourne.contributor.authorFinch, Susan
melbourne.contributor.authorLacorcia, Lauren
dc.identifier.eissn1939-1676
pubs.acceptance.date2020-05-22
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record