An Erg-driven transcriptional program controls B cell lymphopoiesis.
AuthorNg, AP; Coughlan, HD; Hediyeh-Zadeh, S; Behrens, K; Johanson, TM; Low, MSY; Bell, CC; Gilan, O; Chan, Y-C; Kueh, AJ; ...
Source TitleNature Communications
PublisherNature Research (part of Springer Nature)
University of Melbourne Author/sNg, Ashley; Tarlinton, David; Nutt, Stephen; Smyth, Gordon; Allan, Rhys; Davis, Melissa; Dawson, Mark; Bell, Charles; Rogers, Kelly; Alexander, Warren; ...
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsNg, A. P., Coughlan, H. D., Hediyeh-Zadeh, S., Behrens, K., Johanson, T. M., Low, M. S. Y., Bell, C. C., Gilan, O., Chan, Y. -C., Kueh, A. J., Boudier, T., Feltham, R., Gabrielyan, A., DiRago, L., Hyland, C. D., Ierino, H., Mifsud, S., Viney, E., Willson, T. ,... Alexander, W. S. (2020). An Erg-driven transcriptional program controls B cell lymphopoiesis.. Nature Communications, 11 (1), https://doi.org/10.1038/s41467-020-16828-y.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296042
B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B cells. This highly regulated process generates clonal immunological diversity via recombination of immunoglobulin V, D and J gene segments. While several transcription factors that control B cell development and V(D)J recombination have been defined, how these processes are initiated and coordinated into a precise regulatory network remains poorly understood. Here, we show that the transcription factor ETS Related Gene (Erg) is essential for early B lymphoid differentiation. Erg initiates a transcriptional network involving the B cell lineage defining genes, Ebf1 and Pax5, which directly promotes expression of key genes involved in V(D)J recombination and formation of the B cell receptor. Complementation of Erg deficiency with a productively rearranged immunoglobulin gene rescued B lineage development, demonstrating that Erg is an essential and stage-specific regulator of the gene regulatory network controlling B lymphopoiesis.
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