Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

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    Author
    Papadimitriou, N; Dimou, N; Tsilidis, KK; Banbury, B; Martin, RM; Lewis, SJ; Kazmi, N; Robinson, TM; Albanes, D; Aleksandrova, K; ...
    Date
    2020-01-30
    Source Title
    NATURE COMMUNICATIONS
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Buchanan, Daniel; Jenkins, Mark; Severi, Gianluca; Lynch, Brigid
    Affiliation
    Clinical Pathology
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Papadimitriou, N., Dimou, N., Tsilidis, K. K., Banbury, B., Martin, R. M., Lewis, S. J., Kazmi, N., Robinson, T. M., Albanes, D., Aleksandrova, K., Berndt, S. I., Bishop, D. T., Brenner, H., Buchanan, D. D., Bueno-de-Mesquita, B., Campbell, P. T., Castellvi-Bel, S., Chan, A. T., Chang-Claude, J. ,... Murphy, N. (2020). Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. NATURE COMMUNICATIONS, 11 (1), https://doi.org/10.1038/s41467-020-14389-8.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/240759
    DOI
    10.1038/s41467-020-14389-8
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992637
    Abstract
    Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

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