Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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Artigas, MS; Wain, LV; Miller, S; Kheirallah, AK; Huffman, JE; Ntalla, I; Shrine, N; Obeidat, M; Trochet, H; McArdle, WL; ...Date
2015-12-01Source Title
Nature CommunicationsPublisher
Nature Research (part of Springer Nature)University of Melbourne Author/s
Jackson, VictoriaAffiliation
Medical Biology (W.E.H.I.)Metadata
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Journal ArticleCitations
Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M. ,... Zeggini, E. (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6 (1), https://doi.org/10.1038/ncomms9658.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
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