Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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    Author
    Artigas, MS; Wain, LV; Miller, S; Kheirallah, AK; Huffman, JE; Ntalla, I; Shrine, N; Obeidat, M; Trochet, H; McArdle, WL; ...
    Date
    2015-12-01
    Source Title
    Nature Communications
    Publisher
    Nature Research (part of Springer Nature)
    University of Melbourne Author/s
    Jackson, Victoria
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M. ,... Zeggini, E. (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6 (1), https://doi.org/10.1038/ncomms9658.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/240852
    DOI
    10.1038/ncomms9658
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825
    Abstract
    Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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