Medicine, Dentistry & Health Sciences Collected Works - Research Publications
Now showing items 1-10 of 333
Mutation screening of ACKR3 and COPS8 in kidney cancer cases from the CONFIRM study
An apparently balanced t(2;3)(q37.3;q13.2) translocation that appears to segregate with renal cell carcinoma (RCC) has indicated potential areas to search for the elusive genetic basis of clear cell RCC. We applied Hi-Plex ...
Pathways to malaria persistence in remote central Vietnam: a mixed-method study of health care and the community
BACKGROUND: There is increasing interest in underlying socio-cultural, economic, environmental and health-system influences on the persistence of malaria. Vietnam is a Mekong regional 'success story' after dramatic declines ...
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
(NATURE PUBLISHING GROUP, 2014-03-01)
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis ...
Target-D: a stratified individually randomized controlled trial of the diamond clinical prediction tool to triage and target treatment for depressive symptoms in general practice: study protocol for a randomized controlled trial
BACKGROUND: Depression is a highly prevalent and costly disorder. Effective treatments are available but are not always delivered to the right person at the right time, with both under- and over-treatment a problem. Up to ...
Lower urgency paediatric injuries: Parent preferences for emergency department or general practitioner care
OBJECTIVES: Injuries are a significant proportion of lower urgency (triage category 4 or 5) child presentations to the EDs in metropolitan Melbourne. The purpose of the present study was to assess parental preferences and ...
Use of home visiting GP services by paediatric patients presenting at emergency departments
(ROYAL AUSTRALIAN COLLEGE GENERAL PRACTITIONERS, 2016-04-01)
BACKGROUND: Children in Australia are infrequent recipients of general practitioner (GP) home visits. OBJECTIVE: The objective of this article is to examine whether parents who brought their child to an emergency department ...
Patients' experience of using primary care services in the context of Indonesian universal health coverage reforms.
BACKGROUND: The World Health Organization (WHO) recommendation on universal coverage has been implemented in Indonesia as Jaminan Kesehatan Nasional (JKN). It was designed to provide people with equitable and high-quality ...
Fine resolution mapping of double-strand break sites for human ribosomal DNA units
(ELSEVIER SCIENCE BV, 2016-12-01)
DNA breakage arises during a variety of biological processes, including transcription, replication and genome rearrangements. In the context of disease, extensive fragmentation of DNA has been described in cancer cells and ...
Atoh1 gene therapy in the cochlea for hair cell regeneration.
INTRODUCTION: The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory nerve endings, all of which degenerate after hearing loss in mammals. Biological approaches ...
Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer
Aberrant DNA methylation is a key feature of breast carcinoma. We aimed to test the association between breast cancer risk and epigenome-wide methylation in DNA from peripheral blood. Nested case-control study within the ...