Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis
AuthorChia, W; Somers, WG; Wang, H
Source TitleJOURNAL OF CELL BIOLOGY
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sSOMERS, WAYNE
Document TypeJournal Article
CitationsChia, W., Somers, W. G. & Wang, H. (2008). Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis. JOURNAL OF CELL BIOLOGY, 180 (2), pp.267-272. https://doi.org/10.1083/jcb.200708159.
Access StatusOpen Access
Over the past decade, many of the key components of the genetic machinery that regulate the asymmetric division of Drosophila melanogaster neural progenitors, neuroblasts, have been identified and their functions elucidated. Studies over the past two years have shown that many of these identified components act to regulate the self-renewal versus differentiation decision and appear to function as tumor suppressors during larval nervous system development. In this paper, we highlight the growing number of molecules that are normally considered to be key regulators of cell cycle events/progression that have recently been shown to impinge on the neuroblast asymmetric division machinery to control asymmetric protein localization and/or the decision to self-renew or differentiate.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References