RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.
AuthorYordanova, IA; Cortés, A; Klotz, C; Kühl, AA; Heimesaat, MM; Cantacessi, C; Hartmann, S; Rausch, S
Source TitleScientific Reports
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sCantacessi, Cinzia
Document TypeJournal Article
CitationsYordanova, I. A., Cortés, A., Klotz, C., Kühl, A. A., Heimesaat, M. M., Cantacessi, C., Hartmann, S. & Rausch, S. (2019). RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.. Sci Rep, 9 (1), pp.20328-. https://doi.org/10.1038/s41598-019-56416-9.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937251
Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with varying susceptibility to Giardia muris infection. Infected BALB/c mice shed significantly more cysts compared with C57BL/6 mice. Impaired control of infection in BALB/c mice was associated with lower Th17 activity and lower IgA levels compared with C57BL/6 mice. The limited metabolic activity, proliferation and cytokine production of Th17 cells in BALB/c mice was associated with higher proportions of intestinal Foxp3+RORγt+ regulatory T cells and BALB/c mice developed increased RORγt+ Treg:Th17 ratios in response to G. muris infection. Furthermore, G. muris colonization led to a significantly reduced evenness in the gut microbial communities of BALB/c mice. Our data indicate that differential susceptibility to Giardia infections may be related to RORγt+ Treg controlling Th17 activity and that changes in the microbiota composition upon Giardia infection partially depend on the host background.
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