Anti-Helicobacter pylori activity of ethoxzolamide.
AuthorModak, JK; Tikhomirova, A; Gorrell, RJ; Rahman, MM; Kotsanas, D; Korman, TM; Garcia-Bustos, J; Kwok, T; Ferrero, RL; Supuran, CT; ...
Source TitleJournal of Enzyme Inhibition and Medicinal Chemistry
PublisherTaylor & Francis Open
University of Melbourne Author/sGarcia-Bustos, Jose
Document TypeJournal Article
CitationsModak, J. K., Tikhomirova, A., Gorrell, R. J., Rahman, M. M., Kotsanas, D., Korman, T. M., Garcia-Bustos, J., Kwok, T., Ferrero, R. L., Supuran, C. T. & Roujeinikova, A. (2019). Anti-Helicobacter pylori activity of ethoxzolamide.. Journal of Enzyme Inhibition and Medicinal Chemistry, 34 (1), pp.1660-1667. https://doi.org/10.1080/14756366.2019.1663416.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759998
Ethoxzolamide (EZA), acetazolamide, and methazolamide are clinically used sulphonamide drugs designed to treat non-bacteria-related illnesses (e.g. glaucoma), but they also show antimicrobial activity against the gastric pathogen Helicobacter pylori. EZA showed the highest activity, and was effective against clinical isolates resistant to metronidazole, clarithromycin, and/or amoxicillin, suggesting that EZA kills H. pylori via mechanisms different from that of these antibiotics. The frequency of single-step spontaneous resistance acquisition by H. pylori was less than 5 × 10-9, showing that resistance to EZA does not develop easily. Resistance was associated with mutations in three genes, including the one that encodes undecaprenyl pyrophosphate synthase, a known target of sulphonamides. The data indicate that EZA impacts multiple targets in killing H. pylori. Our findings suggest that developing the approved anti-glaucoma drug EZA into a more effective anti-H. pylori agent may offer a faster and cost-effective route towards new antimicrobials with a novel mechanism of action.
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