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dc.contributor.authorOoi, L
dc.contributor.authorDottori, M
dc.contributor.authorCook, AL
dc.contributor.authorEngel, M
dc.contributor.authorGautam, V
dc.contributor.authorGrubman, A
dc.contributor.authorHernandez, D
dc.contributor.authorKing, AE
dc.contributor.authorMaksour, S
dc.contributor.authorAnastacio, HTD
dc.contributor.authorBalez, R
dc.contributor.authorPebay, A
dc.contributor.authorPouton, C
dc.contributor.authorValenzuela, M
dc.contributor.authorWhite, A
dc.contributor.authorWilliamson, R
dc.date.accessioned2020-11-17T03:17:09Z
dc.date.available2020-11-17T03:17:09Z
dc.date.issued2020-10
dc.identifier.citationOoi, L., Dottori, M., Cook, A. L., Engel, M., Gautam, V., Grubman, A., Hernandez, D., King, A. E., Maksour, S., Anastacio, H. T. D., Balez, R., Pebay, A., Pouton, C., Valenzuela, M., White, A. & Williamson, R. (2020). If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?. The Neuroscientist, 26 (5-6), pp.438-454. https://doi.org/10.1177/1073858420912404.
dc.identifier.issn1073-8584
dc.identifier.urihttp://hdl.handle.net/11343/251460
dc.description.abstractBecause our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the “mini-brain,” the “brain in a dish”. At the same time, the ethical issues around organoids are only now being explored. What are the prospects of using human cerebral organoids to better understand, treat, or prevent dementia? Will human organoids represent an improvement on the current, less-than-satisfactory, animal models? When considering these questions, two major issues arise. One is the general challenge associated with using any stem cell–generated preparation for in vitro modelling (challenges amplified when using organoids compared with simpler cell culture systems). The other relates to complexities associated with defining and understanding what we mean by the term “dementia.” We discuss 10 puzzles, issues, and stumbling blocks to watch for in the quest to model “dementia in a dish.”
dc.languageEnglish
dc.publisherSage Publications
dc.titleIf Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?
dc.typeJournal Article
dc.identifier.doi10.1177/1073858420912404
melbourne.affiliation.departmentBiomedical Engineering
melbourne.affiliation.departmentSurgery (RMH)
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.departmentPharmacology and Therapeutics
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.source.titleThe Neuroscientist: reviews at the interface of basic and clinical neurosciences
melbourne.source.volume26
melbourne.source.issue5-6
melbourne.source.pages438-454
melbourne.identifier.nhmrc1097461
melbourne.identifier.nhmrc1154389
melbourne.identifier.arcFT140100047
melbourne.identifier.arcDE180100775
dc.rights.licenseCC BY-NC
melbourne.elementsid1445101
melbourne.contributor.authorPebay, Alice
melbourne.contributor.authorWilliamson, Robert
melbourne.contributor.authorDottori, Mirella
melbourne.contributor.authorWhite, Anthony
melbourne.contributor.authorGautam, Vini
melbourne.contributor.authorHernandez De Santiago, Hector
dc.identifier.eissn1089-4098
melbourne.identifier.fundernameidAustralian Research Council, FT140100047
melbourne.identifier.fundernameidAustralian Research Council, DE180100775
melbourne.identifier.fundernameidNHMRC, 1097461
melbourne.identifier.fundernameidNHMRC, 1154389
melbourne.accessrightsOpen Access


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