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dc.contributor.authorGiuliano, C
dc.contributor.authorLevinger, I
dc.contributor.authorVogrin, S
dc.contributor.authorNeil, CJ
dc.contributor.authorAllen, JD
dc.date.accessioned2020-11-17T03:17:37Z
dc.date.available2020-11-17T03:17:37Z
dc.date.issued2020-04-15
dc.identifier.citationGiuliano, C., Levinger, I., Vogrin, S., Neil, C. J. & Allen, J. D. (2020). PRIME-HF: Novel Exercise for Older Patients with Heart Failure. A Pilot Randomized Controlled Study. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 68 (9), pp.1954-1961. https://doi.org/10.1111/jgs.16428.
dc.identifier.issn0002-8614
dc.identifier.urihttp://hdl.handle.net/11343/251462
dc.description.abstractOBJECTIVES: To test the hypothesis that (1) older patients with heart failure (HF) can tolerate COMBined moderate-intensity aerobic and resistance training (COMBO), and (2) 4 weeks of Peripheral Remodeling through Intermittent Muscular Exercise (PRIME) before 4 weeks of COMBO will improve aerobic capacity and muscle strength to a greater extent than 8 weeks of COMBO. DESIGN: Prospective randomized parallel open-label blinded end point. SETTING: Single-site Australian metropolitan hospital. PARTICIPANTS: Nineteen adults (72.8 ± 8.4 years of age) with heart failure with reduced ejection fraction (HFrEF). INTERVENTION: Participants were randomized to 4 weeks of PRIME or COMBO (phase 1). All participants subsequently completed 4 weeks of COMBO (phase 2). Sessions were twice a week for 60 minutes. PRIME is a low-mass, high-repetition regime (40% one-repetition maximum [1RM], eight strength exercises, 5 minutes each). COMBO training involved combined aerobic (40%-60% of peak aerobic capacity [VO2peak ], up to 20 minutes) and resistance training (50-70% 1RM, eight exercises, two sets of 10 repetitions). MEASUREMENTS: We measured VO2peak , VO2 at anaerobic threshold (AT), and muscle voluntary contraction (MVC). RESULTS: The PRIME group significantly increased VO2peak after 8 weeks (2.4 mL/kg/min; 95% confidence interval [CI] = .7-4.1; P = .004), whereas the COMBO group showed minimal change (.2; 95% CI -1.5 to 1.8). This produced a large between-group effect size of 1.0. VO2 at AT increased in the PRIME group (1.6 mL/kg/min; 95% CI .0-3.2) but not in the COMBO group (-1.2; 95% CI -2.9 to .4), producing a large between-group effect size. Total MVC increased significantly in both groups in comparison with baseline; however, the change was larger in the COMBO group (effect size = .6). CONCLUSION: Traditional exercise approaches (COMBO) and PRIME improved strength. Only PRIME training produced statistically and clinically significant improvements to aerobic capacity. Taken together, these findings support the hypothesis that PRIME may have potential advantages for older patients with HFrEF and could be a possible alternative exercise modality.
dc.languageEnglish
dc.publisherWILEY
dc.titlePRIME-HF: Novel Exercise for Older Patients with Heart Failure. A Pilot Randomized Controlled Study
dc.typeJournal Article
dc.identifier.doi10.1111/jgs.16428
melbourne.affiliation.departmentMedicine and Radiology
melbourne.source.titleJournal of the American Geriatrics Society
melbourne.source.volume68
melbourne.source.issue9
melbourne.source.pages1954-1961
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1446302
melbourne.contributor.authorVogrin, Sara
melbourne.contributor.authorNeil, Christopher
melbourne.contributor.authorLevinger, Itamar
dc.identifier.eissn1532-5415
melbourne.accessrightsOpen Access


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