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    Early-phase [F-18]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

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    Author
    Beyer, L; Nitschmann, A; Barthel, H; van Eimeren, T; Unterrainer, M; Sauerbeck, J; Marek, K; Song, M; Palleis, C; Respondek, G; ...
    Date
    2020-04-21
    Source Title
    European Journal of Nuclear Medicine and Molecular Imaging
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Villemagne, Victor
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Beyer, L., Nitschmann, A., Barthel, H., van Eimeren, T., Unterrainer, M., Sauerbeck, J., Marek, K., Song, M., Palleis, C., Respondek, G., Hammes, J., Barbe, M. T., Onur, O., Jessen, F., Saur, D., Schroeter, M. L., Rumpf, J. -J., Rullmann, M., Schildan, A. ,... Brendel, M. (2020). Early-phase [F-18]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 47 (12), pp.2911-2922. https://doi.org/10.1007/s00259-020-04788-w.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251469
    DOI
    10.1007/s00259-020-04788-w
    Abstract
    PURPOSE: Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). METHODS: Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0-60 min p.i.) and static [18F]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. RESULTS: Highest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers. CONCLUSION: Early-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.

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