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dc.contributor.authorBeyer, L
dc.contributor.authorNitschmann, A
dc.contributor.authorBarthel, H
dc.contributor.authorvan Eimeren, T
dc.contributor.authorUnterrainer, M
dc.contributor.authorSauerbeck, J
dc.contributor.authorMarek, K
dc.contributor.authorSong, M
dc.contributor.authorPalleis, C
dc.contributor.authorRespondek, G
dc.contributor.authorHammes, J
dc.contributor.authorBarbe, MT
dc.contributor.authorOnur, O
dc.contributor.authorJessen, F
dc.contributor.authorSaur, D
dc.contributor.authorSchroeter, ML
dc.contributor.authorRumpf, J-J
dc.contributor.authorRullmann, M
dc.contributor.authorSchildan, A
dc.contributor.authorPatt, M
dc.contributor.authorNeumaier, B
dc.contributor.authorBarret, O
dc.contributor.authorMadonia, J
dc.contributor.authorRussell, DS
dc.contributor.authorStephens, AW
dc.contributor.authorRoeber, S
dc.contributor.authorHerms, J
dc.contributor.authorBoetzel, K
dc.contributor.authorLevin, J
dc.contributor.authorClassen, J
dc.contributor.authorHoeglinger, GU
dc.contributor.authorBartenstein, P
dc.contributor.authorVillemagne, V
dc.contributor.authorDrzezga, A
dc.contributor.authorSeibyl, J
dc.contributor.authorSabri, O
dc.contributor.authorBrendel, M
dc.date.accessioned2020-11-17T03:19:20Z
dc.date.available2020-11-17T03:19:20Z
dc.date.issued2020-04-21
dc.identifierpii: 10.1007/s00259-020-04788-w
dc.identifier.citationBeyer, L., Nitschmann, A., Barthel, H., van Eimeren, T., Unterrainer, M., Sauerbeck, J., Marek, K., Song, M., Palleis, C., Respondek, G., Hammes, J., Barbe, M. T., Onur, O., Jessen, F., Saur, D., Schroeter, M. L., Rumpf, J. -J., Rullmann, M., Schildan, A. ,... Brendel, M. (2020). Early-phase [F-18]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 47 (12), pp.2911-2922. https://doi.org/10.1007/s00259-020-04788-w.
dc.identifier.issn1619-7070
dc.identifier.urihttp://hdl.handle.net/11343/251469
dc.description.abstractPURPOSE: Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). METHODS: Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0-60 min p.i.) and static [18F]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. RESULTS: Highest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers. CONCLUSION: Early-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEarly-phase [F-18]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
dc.typeJournal Article
dc.identifier.doi10.1007/s00259-020-04788-w
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleEuropean Journal of Nuclear Medicine and Molecular Imaging
melbourne.source.volume47
melbourne.source.issue12
melbourne.source.pages2911-2922
dc.rights.licenseCC BY
melbourne.elementsid1447378
melbourne.contributor.authorVillemagne, Victor
dc.identifier.eissn1619-7089
melbourne.accessrightsOpen Access


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