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    Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance

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    Author
    Pedrini, S; Hone, E; Gupta, VB; James, I; Teimouri, E; Bush, A; Rowe, CC; Villemagne, VL; Ames, D; Masters, CL; ...
    Date
    2020-01-01
    Source Title
    Journal of Alzheimer's Disease
    Publisher
    IOS PRESS
    University of Melbourne Author/s
    Masters, Colin; Rowe, Christopher; Villemagne, Victor; Ames, David; Bush, Ashley
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Psychiatry
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Pedrini, S., Hone, E., Gupta, V. B., James, I., Teimouri, E., Bush, A., Rowe, C. C., Villemagne, V. L., Ames, D., Masters, C. L., Rainey-Smith, S., Verdile, G., Sohrabi, H. R., Raida, M. R., Wenk, M. R., Taddei, K., Chatterjee, P., Martins, I., Laws, S. M. & Martins, R. N. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance. JOURNAL OF ALZHEIMERS DISEASE, 77 (2), pp.733-744. https://doi.org/10.3233/JAD-200291.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251524
    DOI
    10.3233/JAD-200291
    Abstract
    BACKGROUND: The link between cholesterol and Alzheimer's disease (AD) has received much attention, as evidence suggests high levels of cholesterol might be an AD risk factor. The carriage of cholesterol and lipids through the body is mediated via lipoproteins, some of which, particularly apolipoprotein E (ApoE), are intimately linked with AD. In humans, high density lipoprotein (HDL) is regarded as a "good" lipid complex due to its ability to enable clearance of excess cholesterol via 'cholesterol reverse transport', although its activities in the pathogenesis of AD are poorly understood. There are several subclasses of HDL; these range from the newly formed small HDL, to much larger HDL. OBJECTIVE: We examined the major subclasses of HDL in healthy controls, mild cognitively impaired, and AD patients who were not taking statins to determine whether there were HDL profile differences between the groups, and whether HDL subclass levels correlated with plasma amyloid-β (Aβ) levels or brain Aβ deposition. METHODS: Samples from AIBL cohort were used in this study. HDL subclass levels were assessed by Lipoprint while Aβ1-42 levels were assessed by ELISA. Brain Aβ deposition was assessed by PET scan. Statistical analysis was performed using parametric and non-parametric tests. RESULTS: We found that small HDL subclass is reduced in AD patients and it correlates with cognitive performance while plasma Aβ concentrations do not correlate with lipid profile or HDL subfraction levels. CONCLUSION: Our data indicate that AD patients exhibit altered plasma HDL profile and that HDL subclasses correlate with cognitive performances.

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