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dc.contributor.authorPedrini, S
dc.contributor.authorHone, E
dc.contributor.authorGupta, VB
dc.contributor.authorJames, I
dc.contributor.authorTeimouri, E
dc.contributor.authorBush, A
dc.contributor.authorRowe, CC
dc.contributor.authorVillemagne, VL
dc.contributor.authorAmes, D
dc.contributor.authorMasters, CL
dc.contributor.authorRainey-Smith, S
dc.contributor.authorVerdile, G
dc.contributor.authorSohrabi, HR
dc.contributor.authorRaida, MR
dc.contributor.authorWenk, MR
dc.contributor.authorTaddei, K
dc.contributor.authorChatterjee, P
dc.contributor.authorMartins, I
dc.contributor.authorLaws, SM
dc.contributor.authorMartins, RN
dc.date.accessioned2020-11-17T03:30:42Z
dc.date.available2020-11-17T03:30:42Z
dc.date.issued2020-01-01
dc.identifierpii: JAD200291
dc.identifier.citationPedrini, S., Hone, E., Gupta, V. B., James, I., Teimouri, E., Bush, A., Rowe, C. C., Villemagne, V. L., Ames, D., Masters, C. L., Rainey-Smith, S., Verdile, G., Sohrabi, H. R., Raida, M. R., Wenk, M. R., Taddei, K., Chatterjee, P., Martins, I., Laws, S. M. & Martins, R. N. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance. JOURNAL OF ALZHEIMERS DISEASE, 77 (2), pp.733-744. https://doi.org/10.3233/JAD-200291.
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/11343/251524
dc.description.abstractBACKGROUND: The link between cholesterol and Alzheimer's disease (AD) has received much attention, as evidence suggests high levels of cholesterol might be an AD risk factor. The carriage of cholesterol and lipids through the body is mediated via lipoproteins, some of which, particularly apolipoprotein E (ApoE), are intimately linked with AD. In humans, high density lipoprotein (HDL) is regarded as a "good" lipid complex due to its ability to enable clearance of excess cholesterol via 'cholesterol reverse transport', although its activities in the pathogenesis of AD are poorly understood. There are several subclasses of HDL; these range from the newly formed small HDL, to much larger HDL. OBJECTIVE: We examined the major subclasses of HDL in healthy controls, mild cognitively impaired, and AD patients who were not taking statins to determine whether there were HDL profile differences between the groups, and whether HDL subclass levels correlated with plasma amyloid-β (Aβ) levels or brain Aβ deposition. METHODS: Samples from AIBL cohort were used in this study. HDL subclass levels were assessed by Lipoprint while Aβ1-42 levels were assessed by ELISA. Brain Aβ deposition was assessed by PET scan. Statistical analysis was performed using parametric and non-parametric tests. RESULTS: We found that small HDL subclass is reduced in AD patients and it correlates with cognitive performance while plasma Aβ concentrations do not correlate with lipid profile or HDL subfraction levels. CONCLUSION: Our data indicate that AD patients exhibit altered plasma HDL profile and that HDL subclasses correlate with cognitive performances.
dc.languageEnglish
dc.publisherIOS PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titlePlasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer's Disease Patients and Correlates with Cognitive Performance
dc.typeJournal Article
dc.identifier.doi10.3233/JAD-200291
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of Alzheimer's Disease
melbourne.source.volume77
melbourne.source.issue2
melbourne.source.pages733-744
dc.rights.licenseCC BY-NC
melbourne.elementsid1460074
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorRowe, Christopher
melbourne.contributor.authorVillemagne, Victor
melbourne.contributor.authorAmes, David
melbourne.contributor.authorBush, Ashley
dc.identifier.eissn1875-8908
melbourne.accessrightsOpen Access


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