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    Definitions and classification of malformations of cortical development: practical guidelines

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    Author
    Severino, M; Geraldo, AF; Utz, N; Tortora, D; Pogledic, I; Klonowski, W; Triulzi, F; Arrigoni, F; Mankad, K; Leventer, RJ; ...
    Date
    2020-10-01
    Source Title
    Brain: a journal of neurology
    Publisher
    OXFORD UNIV PRESS
    University of Melbourne Author/s
    Leventer, Richard
    Affiliation
    Paediatrics (RCH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Severino, M., Geraldo, A. F., Utz, N., Tortora, D., Pogledic, I., Klonowski, W., Triulzi, F., Arrigoni, F., Mankad, K., Leventer, R. J., Mancini, G. M. S., Barkovich, J. A., Lequin, M. H. & Rossi, A. (2020). Definitions and classification of malformations of cortical development: practical guidelines. BRAIN, 143 (10), pp.2874-2894. https://doi.org/10.1093/brain/awaa174.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251530
    DOI
    10.1093/brain/awaa174
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586092
    Abstract
    Malformations of cortical development are a group of rare disorders commonly manifesting with developmental delay, cerebral palsy or seizures. The neurological outcome is extremely variable depending on the type, extent and severity of the malformation and the involved genetic pathways of brain development. Neuroimaging plays an essential role in the diagnosis of these malformations, but several issues regarding malformations of cortical development definitions and classification remain unclear. The purpose of this consensus statement is to provide standardized malformations of cortical development terminology and classification for neuroradiological pattern interpretation. A committee of international experts in paediatric neuroradiology prepared systematic literature reviews and formulated neuroimaging recommendations in collaboration with geneticists, paediatric neurologists and pathologists during consensus meetings in the context of the European Network Neuro-MIG initiative on Brain Malformations (https://www.neuro-mig.org/). Malformations of cortical development neuroimaging features and practical recommendations are provided to aid both expert and non-expert radiologists and neurologists who may encounter patients with malformations of cortical development in their practice, with the aim of improving malformations of cortical development diagnosis and imaging interpretation worldwide.

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