A Biobank of Colorectal Cancer Patient-Derived Xenografts
AuthorAbdirahman, SM; Christie, M; Preaudet, A; Burstroem, MCU; Mouradov, D; Lee, B; Sieber, OM; Putoczki, TL
University of Melbourne Author/sChristie, Michael; Sieber, Oliver; Mouradov, Dmitri; Putoczki, Tracy; Lee, Belinda
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsAbdirahman, S. M., Christie, M., Preaudet, A., Burstroem, M. C. U., Mouradov, D., Lee, B., Sieber, O. M. & Putoczki, T. L. (2020). A Biobank of Colorectal Cancer Patient-Derived Xenografts. CANCERS, 12 (9), https://doi.org/10.3390/cancers12092340.
Access StatusOpen Access
Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly for late-stage disease. Patient-derived xenografts (PDXs) have emerged as an informative, renewable experimental resource to model CRC architecture and biology. Here, we describe the generation of a biobank of CRC PDXs from stage I to stage IV patients. We demonstrate that PDXs within our biobank recapitulate the histopathological and mutation features of the original patient tumor. In addition, we demonstrate the utility of this resource in pre-clinical chemotherapy and targeted treatment studies, highlighting the translational potential of PDX models in the identification of new therapies that will improve the overall survival of CRC patients.
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