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    A Biobank of Colorectal Cancer Patient-Derived Xenografts

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    Author
    Abdirahman, SM; Christie, M; Preaudet, A; Burstroem, MCU; Mouradov, D; Lee, B; Sieber, OM; Putoczki, TL
    Date
    2020-09-01
    Source Title
    Cancers
    Publisher
    MDPI
    University of Melbourne Author/s
    Christie, Michael; Sieber, Oliver; Mouradov, Dmitri; Putoczki, Tracy; Lee, Belinda
    Affiliation
    Medical Biology (W.E.H.I.)
    Clinical Pathology
    Surgery (RMH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Abdirahman, S. M., Christie, M., Preaudet, A., Burstroem, M. C. U., Mouradov, D., Lee, B., Sieber, O. M. & Putoczki, T. L. (2020). A Biobank of Colorectal Cancer Patient-Derived Xenografts. CANCERS, 12 (9), https://doi.org/10.3390/cancers12092340.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251537
    DOI
    10.3390/cancers12092340
    Abstract
    Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly for late-stage disease. Patient-derived xenografts (PDXs) have emerged as an informative, renewable experimental resource to model CRC architecture and biology. Here, we describe the generation of a biobank of CRC PDXs from stage I to stage IV patients. We demonstrate that PDXs within our biobank recapitulate the histopathological and mutation features of the original patient tumor. In addition, we demonstrate the utility of this resource in pre-clinical chemotherapy and targeted treatment studies, highlighting the translational potential of PDX models in the identification of new therapies that will improve the overall survival of CRC patients.

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