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    Can data from paediatric cohorts solve the COVID-19 puzzle?

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    Author
    Do, LAH; Anderson, J; Mulholland, EK; Licciardi, PV
    Date
    2020-09
    Source Title
    PLoS Pathogens
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    Mulholland, Edward; Licciardi, Paul; Do, Lien Anh Ha
    Affiliation
    Paediatrics (RCH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Do, L. A. H., Anderson, J., Mulholland, E. K. & Licciardi, P. V. (2020). Can data from paediatric cohorts solve the COVID-19 puzzle?. PLoS Pathog, 16 (9), pp.e1008798-. https://doi.org/10.1371/journal.ppat.1008798.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251577
    DOI
    10.1371/journal.ppat.1008798
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480854
    Abstract
    COVID-19, caused by SARS-CoV-2, is significantly more severe in adults than in children. The biological reasons for this difference remain to be elucidated. We have compared the most recent virological and immunological data related to COVID-19 between adults and children and contrasted this with earlier data from severe acute respiratory syndrome (SARS) caused by the related SARS-CoV-1 in 2003. Based on these available data, a number of hypotheses are proposed to explain the difference in COVID-19 clinical outcomes between adults and children. NF-kB may be a key factor that could explain the severe clinical manifestations of COVID-19 in adults as well as rare complications associated with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in paediatric COVID-19 patients.

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