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dc.contributor.authorDo, LAH
dc.contributor.authorAnderson, J
dc.contributor.authorMulholland, EK
dc.contributor.authorLicciardi, PV
dc.date.accessioned2020-11-17T03:40:39Z
dc.date.available2020-11-17T03:40:39Z
dc.date.issued2020-09-01
dc.identifierpii: PPATHOGENS-D-20-00964
dc.identifier.citationDo, L. A. H., Anderson, J., Mulholland, E. K. & Licciardi, P. V. (2020). Can data from paediatric cohorts solve the COVID-19 puzzle?. PLOS PATHOGENS, 16 (9), https://doi.org/10.1371/journal.ppat.1008798.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/251577
dc.description.abstractCOVID-19, caused by SARS-CoV-2, is significantly more severe in adults than in children. The biological reasons for this difference remain to be elucidated. We have compared the most recent virological and immunological data related to COVID-19 between adults and children and contrasted this with earlier data from severe acute respiratory syndrome (SARS) caused by the related SARS-CoV-1 in 2003. Based on these available data, a number of hypotheses are proposed to explain the difference in COVID-19 clinical outcomes between adults and children. NF-kB may be a key factor that could explain the severe clinical manifestations of COVID-19 in adults as well as rare complications associated with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in paediatric COVID-19 patients.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCan data from paediatric cohorts solve the COVID-19 puzzle?
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1008798
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titlePLoS Pathogens
melbourne.source.volume16
melbourne.source.issue9
melbourne.source.pagese1008798-
dc.rights.licenseCC BY
melbourne.elementsid1464629
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480854
melbourne.contributor.authorMulholland, Edward
melbourne.contributor.authorLicciardi, Paul
melbourne.contributor.authorDo, Lien Anh Ha
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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