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    Sympathetic nerves control bacterial clearance

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    Author
    Lankadeva, YR; May, CN; McKinley, MJ; Neeland, MR; Ma, S; Hocking, DM; Robins-Browne, R; Bedoui, S; Farmer, DGS; Bailey, SR; ...
    Date
    2020-09-14
    Source Title
    Scientific Reports
    Publisher
    NATURE RESEARCH
    University of Melbourne Author/s
    May, Clive; Bailey, Simon; McAllen, Robin; Hocking, Dianna; Bedoui, Sammy; Robins-Browne, Roy; Farmer, David; Lankadeva, Yugeesh; McKinley, Michael; Martelli, Davide; ...
    Affiliation
    Veterinary Biosciences
    Florey Department of Neuroscience and Mental Health
    Microbiology and Immunology
    Pharmacology and Therapeutics
    Physiology
    Paediatrics (RCH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Lankadeva, Y. R., May, C. N., McKinley, M. J., Neeland, M. R., Ma, S., Hocking, D. M., Robins-Browne, R., Bedoui, S., Farmer, D. G. S., Bailey, S. R., Martelli, D. & McAllen, R. M. (2020). Sympathetic nerves control bacterial clearance. SCIENTIFIC REPORTS, 10 (1), https://doi.org/10.1038/s41598-020-72008-4.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251591
    DOI
    10.1038/s41598-020-72008-4
    Abstract
    A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but its consequences for host responses to live infection are unknown. To test this, conscious instrumented sheep were infected intravenously with live E. coli bacteria and followed for 48 h. A month previously, animals had undergone either bilateral splanchnic nerve section or a sham operation. As established for rodents, sheep with cut splanchnic nerves mounted a stronger systemic inflammatory response: higher blood levels of tumor necrosis factor alpha and interleukin-6 but lower levels of the anti-inflammatory cytokine interleukin-10, compared with sham-operated animals. Sequential blood cultures revealed that most sham-operated sheep maintained high circulating levels of live E. coli throughout the 48-h study period, while all sheep without splanchnic nerves rapidly cleared their bacteraemia and recovered clinically. The sympathetic inflammatory reflex evidently has a profound influence on the clearance of systemic bacterial infection.

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    • Microbiology & Immunology - Research Publications [2198]
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