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dc.contributor.authorLankadeva, YR
dc.contributor.authorMay, CN
dc.contributor.authorMcKinley, MJ
dc.contributor.authorNeeland, MR
dc.contributor.authorMa, S
dc.contributor.authorHocking, DM
dc.contributor.authorRobins-Browne, R
dc.contributor.authorBedoui, S
dc.contributor.authorFarmer, DGS
dc.contributor.authorBailey, SR
dc.contributor.authorMartelli, D
dc.contributor.authorMcAllen, RM
dc.date.accessioned2020-11-17T03:45:16Z
dc.date.available2020-11-17T03:45:16Z
dc.date.issued2020-09-14
dc.identifierpii: 10.1038/s41598-020-72008-4
dc.identifier.citationLankadeva, Y. R., May, C. N., McKinley, M. J., Neeland, M. R., Ma, S., Hocking, D. M., Robins-Browne, R., Bedoui, S., Farmer, D. G. S., Bailey, S. R., Martelli, D. & McAllen, R. M. (2020). Sympathetic nerves control bacterial clearance. SCIENTIFIC REPORTS, 10 (1), https://doi.org/10.1038/s41598-020-72008-4.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/251591
dc.description.abstractA neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but its consequences for host responses to live infection are unknown. To test this, conscious instrumented sheep were infected intravenously with live E. coli bacteria and followed for 48 h. A month previously, animals had undergone either bilateral splanchnic nerve section or a sham operation. As established for rodents, sheep with cut splanchnic nerves mounted a stronger systemic inflammatory response: higher blood levels of tumor necrosis factor alpha and interleukin-6 but lower levels of the anti-inflammatory cytokine interleukin-10, compared with sham-operated animals. Sequential blood cultures revealed that most sham-operated sheep maintained high circulating levels of live E. coli throughout the 48-h study period, while all sheep without splanchnic nerves rapidly cleared their bacteraemia and recovered clinically. The sympathetic inflammatory reflex evidently has a profound influence on the clearance of systemic bacterial infection.
dc.languageEnglish
dc.publisherNATURE RESEARCH
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSympathetic nerves control bacterial clearance
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-020-72008-4
melbourne.affiliation.departmentVeterinary Biosciences
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentPharmacology and Therapeutics
melbourne.affiliation.departmentPhysiology
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleScientific Reports
melbourne.source.volume10
melbourne.source.issue1
melbourne.identifier.nhmrc1186382
dc.rights.licenseCC BY
melbourne.elementsid1465553
melbourne.contributor.authorMay, Clive
melbourne.contributor.authorBailey, Simon
melbourne.contributor.authorMcAllen, Robin
melbourne.contributor.authorHocking, Dianna
melbourne.contributor.authorBedoui, Sammy
melbourne.contributor.authorRobins-Browne, Roy
melbourne.contributor.authorFarmer, David
melbourne.contributor.authorLankadeva, Yugeesh
melbourne.contributor.authorMcKinley, Michael
melbourne.contributor.authorMartelli, Davide
melbourne.contributor.authorNeeland, Melanie
dc.identifier.eissn2045-2322
melbourne.identifier.fundernameidNHMRC, 1186382
melbourne.accessrightsOpen Access


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