University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Multiple Sclerosis as a Syndrome-Implications for Future Management

    Thumbnail
    Download
    published version (1.569Mb)

    Citations
    Altmetric
    Author
    Dwyer, CM; Nguyen, LT-T; Healy, LM; Dutta, R; Ludwin, S; Antel, J; Binder, MD; Kilpatrick, TJ
    Date
    2020-08-28
    Source Title
    Frontiers in Neurology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Kilpatrick, Trevor; Binder, Michele
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Anatomy and Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Dwyer, C. M., Nguyen, L. T. -T., Healy, L. M., Dutta, R., Ludwin, S., Antel, J., Binder, M. D. & Kilpatrick, T. J. (2020). Multiple Sclerosis as a Syndrome-Implications for Future Management. FRONTIERS IN NEUROLOGY, 11, https://doi.org/10.3389/fneur.2020.00784.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251598
    DOI
    10.3389/fneur.2020.00784
    Abstract
    We propose that multiple sclerosis (MS) is best characterized as a syndrome rather than a single disease because different pathogenetic mechanisms can result in the constellation of symptoms and signs by which MS is clinically characterized. We describe several cellular mechanisms that could generate inflammatory demyelination through disruption of homeostatic interactions between immune and neural cells. We illustrate that genomics is important in identifying phenocopies, in particular for primary progressive MS. We posit that molecular profiling, rather than traditional clinical phenotyping, will facilitate meaningful patient stratification, as illustrated by interactions between HLA and a regulator of homeostatic phagocytosis, MERTK. We envisage a personalized approach to MS management where genetic, molecular, and cellular information guides management.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52443]
    • Anatomy and Neuroscience - Research Publications [804]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1312]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors