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dc.contributor.authorDwyer, CM
dc.contributor.authorNguyen, LT-T
dc.contributor.authorHealy, LM
dc.contributor.authorDutta, R
dc.contributor.authorLudwin, S
dc.contributor.authorAntel, J
dc.contributor.authorBinder, MD
dc.contributor.authorKilpatrick, TJ
dc.date.accessioned2020-11-17T03:46:48Z
dc.date.available2020-11-17T03:46:48Z
dc.date.issued2020-08-28
dc.identifier.citationDwyer, C. M., Nguyen, L. T. -T., Healy, L. M., Dutta, R., Ludwin, S., Antel, J., Binder, M. D. & Kilpatrick, T. J. (2020). Multiple Sclerosis as a Syndrome-Implications for Future Management. FRONTIERS IN NEUROLOGY, 11, https://doi.org/10.3389/fneur.2020.00784.
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/11343/251598
dc.description.abstractWe propose that multiple sclerosis (MS) is best characterized as a syndrome rather than a single disease because different pathogenetic mechanisms can result in the constellation of symptoms and signs by which MS is clinically characterized. We describe several cellular mechanisms that could generate inflammatory demyelination through disruption of homeostatic interactions between immune and neural cells. We illustrate that genomics is important in identifying phenocopies, in particular for primary progressive MS. We posit that molecular profiling, rather than traditional clinical phenotyping, will facilitate meaningful patient stratification, as illustrated by interactions between HLA and a regulator of homeostatic phagocytosis, MERTK. We envisage a personalized approach to MS management where genetic, molecular, and cellular information guides management.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMultiple Sclerosis as a Syndrome-Implications for Future Management
dc.typeJournal Article
dc.identifier.doi10.3389/fneur.2020.00784
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.source.titleFrontiers in Neurology
melbourne.source.volume11
dc.rights.licenseCC BY
melbourne.elementsid1466007
melbourne.contributor.authorKilpatrick, Trevor
melbourne.contributor.authorBinder, Michele
melbourne.contributor.authorNguyen, Linda
dc.identifier.eissn1664-2295
melbourne.accessrightsOpen Access


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