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dc.contributor.authorAbdullah, A
dc.contributor.authorMobilio, F
dc.contributor.authorCrack, PJ
dc.contributor.authorTaylor, JM
dc.date.accessioned2020-11-17T03:55:27Z
dc.date.available2020-11-17T03:55:27Z
dc.date.issued2020-10-01
dc.identifierpii: ijms21197059
dc.identifier.citationAbdullah, A., Mobilio, F., Crack, P. J. & Taylor, J. M. (2020). STING-Mediated Autophagy Is Protective against H2O2-Induced Cell Death. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (19), https://doi.org/10.3390/ijms21197059.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11343/251642
dc.description.abstractStimulator of interferon genes (STING)-mediated type-I interferon signaling is a well characterized instigator of the innate immune response following bacterial or viral infections in the periphery. Emerging evidence has recently linked STING to various neuropathological conditions, however, both protective and deleterious effects of the pathway have been reported. Elevated oxidative stress, such as neuroinflammation, is a feature of a number of neuropathologies, therefore, this study investigated the role of the STING pathway in cell death induced by elevated oxidative stress. Here, we report that the H2O2-induced activation of the STING pathway is protective against cell death in wildtype (WT) MEFSV40 cells as compared to STING-/- MEF SV40 cells. This protective effect of STING can be attributed, in part, to an increase in autophagy flux with an increased LC3II/I ratio identified in H2O2-treated WT cells as compared to STING-/- cells. STING-/- cells also exhibited impaired autophagic flux as indicated by p62, LC3-II and LAMP2 accumulation following H2O2 treatment, suggestive of an impairment at the autophagosome-lysosomal fusion step. This indicates a previously unrecognized role for STING in maintaining efficient autophagy flux and protecting against H2O2-induced cell death. This finding supports a multifaceted role for the STING pathway in the underlying cellular mechanisms contributing to the pathogenesis of neurological disorders.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSTING-Mediated Autophagy Is Protective against H2O2-Induced Cell Death
dc.typeJournal Article
dc.identifier.doi10.3390/ijms21197059
melbourne.affiliation.departmentPharmacology and Therapeutics
melbourne.source.titleInternational Journal of Molecular Sciences
melbourne.source.volume21
melbourne.source.issue19
melbourne.source.pages1-17
dc.rights.licenseCC BY
melbourne.elementsid1466947
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582849
melbourne.contributor.authorTaylor, Juliet
melbourne.contributor.authorCrack, Peter
melbourne.contributor.authorAbdullah, Amar
melbourne.contributor.authorMobilio, Frank
dc.identifier.eissn1422-0067
melbourne.accessrightsOpen Access


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