High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite
Web of Science
AuthorKorhonen, PK; Gasser, RB; Ma, G; Wang, T; Stroehlein, AJ; Young, ND; Ang, C-S; Fernando, DD; Lu, HC; Taylor, S; ...
Source TitlePLoS Neglected Tropical Diseases
PublisherPUBLIC LIBRARY SCIENCE
University of Melbourne Author/sAng, Ching-Seng; Young, Neil; Gasser, Robin; Korhonen, Pasi; Stroehlein, Andreas; Wang, Tao
Document TypeJournal Article
CitationsKorhonen, P. K., Gasser, R. B., Ma, G., Wang, T., Stroehlein, A. J., Young, N. D., Ang, C. -S., Fernando, D. D., Lu, H. C., Taylor, S., Reynolds, S. L., Mofiz, E., Najaraj, S. H., Gowda, H., Madugundu, A., Renuse, S., Holt, D., Pandey, A., Papenfuss, A. T. & Fischer, K. (2020). High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. PLOS NEGLECTED TROPICAL DISEASES, 14 (10), https://doi.org/10.1371/journal.pntd.0008720.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591027
The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
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