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    Associations between vascular risk factors and subsequent Alzheimer's disease in older adults.

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    Author
    Lee, H; Kim, K; Lee, YC; Kim, S; Won, H-H; Yu, TY; Lee, E-M; Kang, JM; Lewis, M; Kim, DK; ...
    Date
    2020-09-26
    Source Title
    Alzheimer's Research and Therapy
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Lewis, Matthew
    Affiliation
    General Practice
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Lee, H., Kim, K., Lee, Y. C., Kim, S., Won, H. -H., Yu, T. Y., Lee, E. -M., Kang, J. M., Lewis, M., Kim, D. K. & Myung, W. (2020). Associations between vascular risk factors and subsequent Alzheimer's disease in older adults.. Alzheimers Res Ther, 12 (1), pp.117-. https://doi.org/10.1186/s13195-020-00690-7.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251690
    DOI
    10.1186/s13195-020-00690-7
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520023
    Abstract
    BACKGROUND: The clinical guidelines related to the primary prevention of Alzheimer's disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older adults remains unclear. This study aimed to determine the association between vascular risk factors and subsequent AD in 178,586 older adults (age ≥ 65 years). METHODS: Participants were recruited from 2009 through 2010 and followed up for 6 years. We assessed various vascular risk factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], fasting glucose [FG], systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], and body mass index [BMI]) and their association with AD incidence, categorizing each vascular factor using current clinical guidelines. RESULTS: AD was observed in 6.0% of participants at follow-up. All lipid profiles (TC, LDL-C, HDL-C and TG) were positively associated with the risk of AD. SBP and PP were in negative associations with AD, and DBP was positively associated with AD. BMI exhibited a negative association with AD incidence. We found no significant association between FG and AD risk. The sex difference was observed to have effects on vascular risk factors. CONCLUSIONS: In this study, we comprehensively investigated the association between eight vascular risk factors and the risk of incident AD. Our findings suggest that multiple vascular risk factors are related to the development of AD in older adults. These results can help inform future guidelines for reducing AD risk.

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