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dc.contributor.authorDinevska, M
dc.contributor.authorGazibegovic, N
dc.contributor.authorMorokoff, AP
dc.contributor.authorKaye, AH
dc.contributor.authorDrummond, KJ
dc.contributor.authorMantamadiotis, T
dc.contributor.authorStylli, SS
dc.date.accessioned2020-11-17T04:04:38Z
dc.date.available2020-11-17T04:04:38Z
dc.date.issued2020-10-01
dc.identifierpii: cancers12102888
dc.identifier.citationDinevska, M., Gazibegovic, N., Morokoff, A. P., Kaye, A. H., Drummond, K. J., Mantamadiotis, T. & Stylli, S. S. (2020). Inhibition of Radiation and Temozolomide-Induced Glioblastoma Invadopodia Activity Using Ion Channel Drugs. CANCERS, 12 (10), https://doi.org/10.3390/cancers12102888.
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/11343/251691
dc.description.abstractGlioblastoma (GBM) is the most prevalent and malignant type of primary brain cancer. The rapid invasion and dissemination of tumor cells into the surrounding normal brain is a major driver of tumor recurrence, and long-term survival of GBM patients is extremely rare. Actin-rich cell membrane protrusions known as invadopodia can facilitate the highly invasive properties of GBM cells. Ion channels have been proposed to contribute to a pro-invasive phenotype in cancer cells and may also be involved in the invadopodia activity of GBM cells. GBM cell cytotoxicity screening of several ion channel drugs identified three drugs with potent cell killing efficacy: flunarizine dihydrochloride, econazole nitrate, and quinine hydrochloride dihydrate. These drugs demonstrated a reduction in GBM cell invadopodia activity and matrix metalloproteinase-2 (MMP-2) secretion. Importantly, the treatment of GBM cells with these drugs led to a significant reduction in radiation/temozolomide-induced invadopodia activity. The dual cytotoxic and anti-invasive efficacy of these agents merits further research into targeting ion channels to reduce GBM malignancy, with a potential for future clinical translation in combination with the standard therapy.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInhibition of Radiation and Temozolomide-Induced Glioblastoma Invadopodia Activity Using Ion Channel Drugs
dc.typeJournal Article
dc.identifier.doi10.3390/cancers12102888
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentSurgery (RMH)
melbourne.affiliation.department
melbourne.source.titleCancers
melbourne.source.volume12
melbourne.source.issue10
dc.rights.licenseCC BY
melbourne.elementsid1468690
melbourne.contributor.authorDinevska, Marija
melbourne.contributor.authorStylli, Stanley
melbourne.contributor.authorMantamadiotis, Theofilos
melbourne.contributor.authorKaye, Andrew
melbourne.contributor.authorMorokoff, Andrew
melbourne.contributor.authorDrummond, Katharine
dc.identifier.eissn2072-6694
melbourne.accessrightsOpen Access


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