Show simple item record

dc.contributor.authorStylli, SS
dc.date.accessioned2020-11-17T04:05:29Z
dc.date.available2020-11-17T04:05:29Z
dc.date.issued2020-10-01
dc.identifierpii: cancers12102883
dc.identifier.citationStylli, S. S. (2020). Novel Treatment Strategies for Glioblastoma. CANCERS, 12 (10), https://doi.org/10.3390/cancers12102883.
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/11343/251696
dc.description.abstractGlioblastoma (GBM) is the most common primary central nervous system tumor in adults. It is a highly invasive disease, making it difficult to achieve a complete surgical resection, resulting in poor prognosis with a median survival of 12-15 months after diagnosis, and less than 5% of patients survive more than 5 years. Surgical, instrument technology, diagnostic and radio/chemotherapeutic strategies have slowly evolved over time, but this has not translated into significant increases in patient survival. The current standard of care for GBM patients involving surgery, radiotherapy, and concomitant chemotherapy temozolomide (known as the Stupp protocol), has only provided a modest increase of 2.5 months in median survival, since the landmark publication in 2005. There has been considerable effort in recent years to increase our knowledge of the molecular landscape of GBM through advances in technology such as next-generation sequencing, which has led to the stratification of the disease into several genetic subtypes. Current treatments are far from satisfactory, and studies investigating acquired/inherent resistance to current therapies, restricted drug delivery, inter/intra-tumoral heterogeneity, drug repurposing and a tumor immune-evasive environment have been the focus of intense research over recent years. While the clinical advancement of GBM therapeutics has seen limited progression compared to other cancers, developments in novel treatment strategies that are being investigated are displaying encouraging signs for combating this disease. This aim of this editorial is to provide a brief overview of a select number of these novel therapeutic approaches.
dc.languageEnglish
dc.publisherMDPI
dc.titleNovel Treatment Strategies for Glioblastoma
dc.typeJournal Article
dc.identifier.doi10.3390/cancers12102883
melbourne.affiliation.departmentSurgery (RMH)
melbourne.source.titleCancers
melbourne.source.volume12
melbourne.source.issue10
melbourne.source.pages1-11
dc.rights.licenseCC BY
melbourne.elementsid1468886
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599818
melbourne.contributor.authorStylli, Stanley
dc.identifier.eissn2072-6694
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record