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    Genome-wide RNAi screen for genes regulating glycolytic response to vemurafenib in BRAF(V600) melanoma cells

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    Author
    Smith, LK; Parmenter, T; Gould, CM; Madhamshettiwar, PB; Sheppard, KE; Simpson, KJ; McArthur, GA
    Date
    2020-10-12
    Source Title
    Scientific Data
    Publisher
    NATURE RESEARCH
    University of Melbourne Author/s
    McArthur, Grant
    Affiliation
    Melbourne Medical School
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Smith, L. K., Parmenter, T., Gould, C. M., Madhamshettiwar, P. B., Sheppard, K. E., Simpson, K. J. & McArthur, G. A. (2020). Genome-wide RNAi screen for genes regulating glycolytic response to vemurafenib in BRAF(V600) melanoma cells. SCIENTIFIC DATA, 7 (1), https://doi.org/10.1038/s41597-020-00683-z.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251714
    DOI
    10.1038/s41597-020-00683-z
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550327
    Abstract
    Identification of mechanisms underlying sensitivity and response to targeted therapies, such as the BRAF inhibitor vemurafenib, is critical in order to improve efficacy of these therapies in the clinic and delay onset of resistance. Glycolysis has emerged as a key feature of the BRAF inhibitor response in melanoma cells, and importantly, the metabolic response to vemurafenib in melanoma patients can predict patient outcome. Here, we present a multiparameter genome-wide siRNA screening dataset of genes that when depleted improve the viability and glycolytic response to vemurafenib in BRAFV600 mutated melanoma cells. These datasets are suitable for analysis of genes involved in cell viability and glycolysis in steady state conditions and following treatment with vemurafenib, as well as computational approaches to identify gene regulatory networks that mediate response to BRAF inhibition in melanoma.

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