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    MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

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    Author
    Whigham, C-A; MacDonald, TM; Walker, SP; Hiscock, R; Hannan, NJ; Pritchard, N; Cannon, P; Tuong, VN; Miranda, M; Tong, S; ...
    Date
    2020-10-22
    Source Title
    Scientific Reports
    Publisher
    NATURE RESEARCH
    University of Melbourne Author/s
    Lino, Tu'uhevaha; Walker, Susan; Tong, Stephen; Cannon, Ping; Nguyen, Tuong-Vi; Whigham, Carole-Anne; MacDonald, Teresa; Hannan, Natalie; Hiscock, Richard; Pritchard, Natasha
    Affiliation
    Obstetrics and Gynaecology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Whigham, C. -A., MacDonald, T. M., Walker, S. P., Hiscock, R., Hannan, N. J., Pritchard, N., Cannon, P., Tuong, V. N., Miranda, M., Tong, S. & Kaitu'u-Lino, T. J. (2020). MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia. SCIENTIFIC REPORTS, 10 (1), https://doi.org/10.1038/s41598-020-73783-w.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251723
    DOI
    10.1038/s41598-020-73783-w
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583242
    NHMRC Grant code
    NHMRC/1065854
    NHMRC/1136418
    NHMRC/1146128
    Abstract
    Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ injury. A predictive test to identify those who will develop preeclampsia could substantially decrease morbidity and mortality. MicroRNAs (miRs) are small RNA molecules involved in post-transcriptional gene regulation. We screened for circulating miRs differentially expressed at 36 weeks' gestation in pregnancies before the development of preeclampsia. We used a case-control group (198 controls, 34 pre-preeclampsia diagnosis) selected from a prospective cohort (n = 2015) and performed a PCR-based microarray to measure the expression of 41 miRs. We found six circulating miRs (miRs 363, 149, 18a, 1283, 16, 424) at 36 weeks' had significantly reduced expression (p < 0.0001-0.04). miR363 was significantly downregulated at 28 weeks' gestation, 10-12 weeks before the onset of clinical disease. In the circulation of another cohort of 34 participants with established preterm preeclampsia (vs 23 controls), we found miRs363, 18a, 149 and 16 were significantly down regulated (p < 0.0001-0.04). Combined expression of miRs149 and 363 in the circulation at 36 weeks' gestation provides a test with 45% sensitivity (at a specificity of 90%) which suggests measuring both miRs may have promise as part of a multi-marker test to predict preeclampsia.

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