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    Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

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    Author
    Josefsson, EC; Vainchenker, W; James, C
    Date
    2020-10-01
    Source Title
    International Journal of Molecular Sciences
    Publisher
    MDPI
    University of Melbourne Author/s
    Josefsson, Emma
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Josefsson, E. C., Vainchenker, W. & James, C. (2020). Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (20), https://doi.org/10.3390/ijms21207591.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/251727
    DOI
    10.3390/ijms21207591
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589436
    Abstract
    Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the prosurvival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes.

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