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dc.contributor.authorLe, HH
dc.contributor.authorShakeri, M
dc.contributor.authorSuleria, HAR
dc.contributor.authorZhao, W
dc.contributor.authorMcQuade, RM
dc.contributor.authorPhillips, DJ
dc.contributor.authorVidacs, E
dc.contributor.authorFurness, JB
dc.contributor.authorDunshea, FR
dc.contributor.authorArtuso-Ponte, V
dc.contributor.authorCottrell, JJ
dc.date.accessioned2020-11-17T04:12:50Z
dc.date.available2020-11-17T04:12:50Z
dc.date.issued2020-10-01
dc.identifierpii: antiox9101024
dc.identifier.citationLe, H. H., Shakeri, M., Suleria, H. A. R., Zhao, W., McQuade, R. M., Phillips, D. J., Vidacs, E., Furness, J. B., Dunshea, F. R., Artuso-Ponte, V. & Cottrell, J. J. (2020). Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs. ANTIOXIDANTS, 9 (10), https://doi.org/10.3390/antiox9101024.
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/11343/251736
dc.description.abstractHeat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory responses, particularly within the gastrointestinal tract. This study aimed to investigate whether plant-derived betaine and isoquinoline alkaloids could ameliorate HS in pigs. Fifty female Large White × Landrace grower pigs, which were acclimated to control (CON), control plus betaine (BET), or control plus isoquinoline alkaloids (IQA) diets for 14 days were then exposed to heat stress or thermoneutral condition. Both BET and IQA partially ameliorated increases in respiration rate (p = 0.013) and rectal temperature (p = 0.001) associated with HS conditions. Heat stress increased salivary cortisol concentrations and reduced plasma creatinine, lactate, and thyroid hormone concentrations. Heat stress increased colon FD4 permeability, which was reduced by IQA (p = 0.030). Heat stress increased inflammation in the jejunum and ileum, as indicated by elevated interleukin-1β (p = 0.022) in the jejunum and interleukin-1β (p = 0.004) and interleukin-8 (p = 0.001) in the ileum. No differences in plasma total antioxidant capacity (TAC) were observed with HS, but betaine increased plasma TAC compared to IQA. Dietary BET increased betaine concentrations in the jejunum, ileum (p < 0.001 for both), plasma, liver, kidney (p < 0.010 for all), urine (p = 0.002) and tended to be higher in muscle (p = 0.084). Betaine concentration was not influenced by HS, but it tended to be higher in plasma and accumulated in the liver. These data suggest that betaine and isoquinoline alkaloids supplementation ameliorated consequences of heat stress in grower pigs and protected against HS induced increases in colonic permeability.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleBetaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs
dc.typeJournal Article
dc.identifier.doi10.3390/antiox9101024
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentAgriculture and Food Systems
melbourne.affiliation.departmentMedicine, Western Health
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyVeterinary and Agricultural Sciences
melbourne.source.titleAntioxidants
melbourne.source.volume9
melbourne.source.issue10
dc.rights.licenseCC BY
melbourne.elementsid1469447
melbourne.contributor.authorSuleria, Hafiz Ansar Rasul
melbourne.contributor.authorDunshea, Frank
melbourne.contributor.authorCottrell, Jeremy
melbourne.contributor.authorLE, HIEU
melbourne.contributor.authorFurness, John
melbourne.contributor.authorMcQuade, Rachel
melbourne.contributor.authorZhao, Weicheng
melbourne.contributor.authorLe, Hieu
melbourne.contributor.authorVidacs, Eva
melbourne.contributor.authorZhao, Wei
dc.identifier.eissn2076-3921
melbourne.accessrightsOpen Access


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