Antibody-Drug Conjugates for Cancer Therapy

Download
Citations
Altmetric
Author
Hafeez, U; Parakh, S; Gan, HK; Scott, AMDate
2020-10-01Source Title
MoleculesPublisher
MDPIAffiliation
Medicine and RadiologyMedical Education
Metadata
Show full item recordDocument Type
Journal ArticleCitations
Hafeez, U., Parakh, S., Gan, H. K. & Scott, A. M. (2020). Antibody-Drug Conjugates for Cancer Therapy. MOLECULES, 25 (20), https://doi.org/10.3390/molecules25204764.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587605Abstract
Antibody-drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry of each component of ADC design. We briefly discuss the clinical experience with approved ADCs and the various pathways involved in ADC resistance. We conclude with perspectives about the future development of the next generations of ADCs, including the role of molecular imaging in drug development.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References