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dc.contributor.authorHafeez, U
dc.contributor.authorParakh, S
dc.contributor.authorGan, HK
dc.contributor.authorScott, AM
dc.date.accessioned2020-11-17T04:13:27Z
dc.date.available2020-11-17T04:13:27Z
dc.date.issued2020-10-01
dc.identifierpii: molecules25204764
dc.identifier.citationHafeez, U., Parakh, S., Gan, H. K. & Scott, A. M. (2020). Antibody-Drug Conjugates for Cancer Therapy. MOLECULES, 25 (20), https://doi.org/10.3390/molecules25204764.
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11343/251739
dc.description.abstractAntibody-drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry of each component of ADC design. We briefly discuss the clinical experience with approved ADCs and the various pathways involved in ADC resistance. We conclude with perspectives about the future development of the next generations of ADCs, including the role of molecular imaging in drug development.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAntibody-Drug Conjugates for Cancer Therapy
dc.typeJournal Article
dc.identifier.doi10.3390/molecules25204764
melbourne.affiliation.departmentMedical Education
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleMolecules
melbourne.source.volume25
melbourne.source.issue20
melbourne.source.pages4764-4764
dc.rights.licenseCC BY
melbourne.elementsid1469578
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587605
melbourne.contributor.authorScott, Andrew
melbourne.contributor.authorGan, Hui
melbourne.contributor.authorHafeez, Umbreen
dc.identifier.eissn1420-3049
melbourne.accessrightsOpen Access


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