Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain
AuthorJamadar, SD; Ward, PGD; Close, TG; Fornito, A; Premaratne, M; O'Brien, K; Stab, D; Chen, Z; Shah, NJ; Egan, GF
Source TitleScientific Data
University of Melbourne Author/sEgan, Gary
AffiliationAnatomy and Neuroscience
Document TypeJournal Article
CitationsJamadar, S. D., Ward, P. G. D., Close, T. G., Fornito, A., Premaratne, M., O'Brien, K., Stab, D., Chen, Z., Shah, N. J. & Egan, G. F. (2020). Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain. SCIENTIFIC DATA, 7 (1), https://doi.org/10.1038/s41597-020-00699-5.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578808
Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain - cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18-20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.
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