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dc.contributor.authorHilvo, M
dc.contributor.authorMeikle, PJ
dc.contributor.authorPedersen, ER
dc.contributor.authorTell, GS
dc.contributor.authorDhar, I
dc.contributor.authorBrenner, H
dc.contributor.authorSchoettker, B
dc.contributor.authorLaaperi, M
dc.contributor.authorKauhanen, D
dc.contributor.authorKoistinen, KM
dc.contributor.authorJylha, A
dc.contributor.authorHuynh, K
dc.contributor.authorMellett, NA
dc.contributor.authorTonkin, AM
dc.contributor.authorSullivan, DR
dc.contributor.authorSimes, J
dc.contributor.authorNestel, P
dc.contributor.authorKoenig, W
dc.contributor.authorRothenbacher, D
dc.contributor.authorNygard, O
dc.contributor.authorLaaksonen, R
dc.date.accessioned2020-11-26T22:43:57Z
dc.date.available2020-11-26T22:43:57Z
dc.date.issued2020-01-14
dc.identifierpii: 5519585
dc.identifier.citationHilvo, M., Meikle, P. J., Pedersen, E. R., Tell, G. S., Dhar, I., Brenner, H., Schoettker, B., Laaperi, M., Kauhanen, D., Koistinen, K. M., Jylha, A., Huynh, K., Mellett, N. A., Tonkin, A. M., Sullivan, D. R., Simes, J., Nestel, P., Koenig, W., Rothenbacher, D. ,... Laaksonen, R. (2020). Development and variation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients. EUROPEAN HEART JOURNAL, 41 (3), pp.371-380. https://doi.org/10.1093/eurheartj/ehz387.
dc.identifier.issn0195-668X
dc.identifier.urihttp://hdl.handle.net/11343/251970
dc.description.abstractAIMS: Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the combination of ceramides with phosphatidylcholines (PCs) would be synergistic in the prediction of CVD events in patients with atherosclerotic coronary heart disease in three independent cohort studies. METHODS AND RESULTS: Ceramides and PCs were analysed using liquid chromatography-mass spectrometry (LC-MS) in three studies: WECAC (The Western Norway Coronary Angiography Cohort) (N = 3789), LIPID (Long-Term Intervention with Pravastatin in Ischaemic Disease) trial (N = 5991), and KAROLA (Langzeiterfolge der KARdiOLogischen Anschlussheilbehandlung) (N = 1023). A simple risk score, based on the ceramides and PCs showing the best prognostic features, was developed in the WECAC study and validated in the two other cohorts. This score was highly significant in predicting CVD mortality [multiadjusted hazard ratios (HRs; 95% confidence interval) per standard deviation were 1.44 (1.28-1.63) in WECAC, 1.47 (1.34-1.61) in the LIPID trial, and 1.69 (1.31-2.17) in KAROLA]. In addition, a combination of the risk score with high-sensitivity troponin T increased the HRs to 1.63 (1.44-1.85) and 2.04 (1.57-2.64) in WECAC and KAROLA cohorts, respectively. The C-statistics in WECAC for the risk score combined with sex and age was 0.76 for CVD death. The ceramide-phospholipid risk score showed comparable and synergistic predictive performance with previously published CVD risk models for secondary prevention. CONCLUSION: A simple ceramide- and phospholipid-based risk score can efficiently predict residual CVD event risk in patients with coronary artery disease.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleDevelopment and variation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients
dc.typeJournal Article
dc.identifier.doi10.1093/eurheartj/ehz387
melbourne.affiliation.departmentBio21
melbourne.affiliation.departmentMelbourne Medical School
melbourne.source.titleEuropean Heart Journal
melbourne.source.volume41
melbourne.source.issue3
melbourne.source.pages371-380
dc.rights.licensecc-by-nc
melbourne.elementsid1432445
melbourne.contributor.authorMeikle, Peter
melbourne.contributor.authorHuynh, Kevin
dc.identifier.eissn1522-9645
melbourne.accessrightsOpen Access


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