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dc.contributor.authorNelson, B
dc.contributor.authorYuen, HP
dc.contributor.authorAmminger, GP
dc.contributor.authorBerger, G
dc.contributor.authorChen, EYH
dc.contributor.authorde Haan, L
dc.contributor.authorHartmann, JA
dc.contributor.authorHickie, IB
dc.contributor.authorLavoie, S
dc.contributor.authorMarkulev, C
dc.contributor.authorMossaheb, N
dc.contributor.authorNieman, DH
dc.contributor.authorNordentoft, M
dc.contributor.authorPolari, A
dc.contributor.authorRiecher-Rössler, A
dc.contributor.authorSchäfer, MR
dc.contributor.authorSchlögelhofer, M
dc.contributor.authorSmesny, S
dc.contributor.authorTedja, A
dc.contributor.authorThompson, A
dc.contributor.authorVerma, S
dc.contributor.authorYung, AR
dc.contributor.authorMcGorry, PD
dc.date.accessioned2020-11-26T22:48:34Z
dc.date.available2020-11-26T22:48:34Z
dc.date.issued2020-03-02
dc.identifierpii: 5771419
dc.identifier.citationNelson, B., Yuen, H. P., Amminger, G. P., Berger, G., Chen, E. Y. H., de Haan, L., Hartmann, J. A., Hickie, I. B., Lavoie, S., Markulev, C., Mossaheb, N., Nieman, D. H., Nordentoft, M., Polari, A., Riecher-Rössler, A., Schäfer, M. R., Schlögelhofer, M., Smesny, S., Tedja, A. ,... McGorry, P. D. (2020). Distress related to attenuated psychotic symptoms: Static and dynamic association with transition to psychosis, non-remission and transdiagnostic symptomatology in clinical high-risk patients in an international intervention trial.. Schizophr Bull, https://doi.org/10.1093/schizbullopen/sgaa006.
dc.identifier.issn1787-9965
dc.identifier.urihttp://hdl.handle.net/11343/251998
dc.description.abstractThis study examined whether distress in relation to attenuated psychotic symptoms (DAPS) is associated with clinical outcomes in an ultra-high-risk (UHR) for psychosis sample. We also investigated whether DAPS is associated with cognitive style (attributional style and cognitive biases) and whether amount of psychosocial treatment provided is associated with reduction in DAPS. The study was a secondary analysis of the 'Neurapro' clinical trial of omega-3 fatty acids. 304 UHR patients were recruited across ten early intervention services. Data from baseline assessment, regular assessments over 12 months and medium term follow up (mean=3.4 years) were used for analysis. Findings indicated: a positive association between DAPS assessed over time and transition to psychosis; a significant positive association between baseline and longitudinal DAPS and transdiagnostic clinical and functional outcomes; a significant positive association between baseline and longitudinal DAPS and non-remission of UHR status. There was no relationship between severity of DAPS and cognitive style. A greater amount of psychosocial treatment (cognitive-behavioural case management) was associated with an increase in DAPS scores. The study indicates that UHR patients who are more distressed by their attenuated psychotic symptoms are more likely to have a poorer clinical trajectory transdiagnostically. Assessment of DAPS may therefore function as a useful marker of risk for a range of poor outcomes. The findings underline the value of repeated assessment of variables and incorporation of dynamic change into predictive modelling. More research is required into mechanisms driving distress associated with symptoms and the possible bidirectional relationship between symptom severity and associated distress.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleDistress related to attenuated psychotic symptoms: Static and dynamic association with transition to psychosis, non-remission and transdiagnostic symptomatology in clinical high-risk patients in an international intervention trial.
dc.typeJournal Article
dc.identifier.doi10.1093/schizbullopen/sgaa006
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleSchizophrenia Bulletin
dc.rights.licensecc-by-nc
melbourne.elementsid1439502
melbourne.contributor.authorAmminger, Guenter
melbourne.contributor.authorYuen, Hok
melbourne.contributor.authorMcGorry, Patrick
melbourne.contributor.authorLavoie, Suzie
melbourne.contributor.authorYung, Alison
melbourne.contributor.authorNelson, Christopher
melbourne.contributor.authorHartmann, Jessica
melbourne.contributor.authorThompson, Andrew
dc.identifier.eissn1745-1701
melbourne.accessrightsOpen Access


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