Show simple item record

dc.contributor.authorChu, AHY
dc.contributor.authorTint, MT
dc.contributor.authorChang, HF
dc.contributor.authorWong, G
dc.contributor.authorYuan, WL
dc.contributor.authorTull, D
dc.contributor.authorNijagal, B
dc.contributor.authorNarayana, VK
dc.contributor.authorMeikle, PJ
dc.contributor.authorChang, KTE
dc.contributor.authorLewis, RM
dc.contributor.authorChi, C
dc.contributor.authorYap, FKP
dc.contributor.authorTan, KH
dc.contributor.authorShek, LP
dc.contributor.authorChong, Y-S
dc.contributor.authorGluckman, PD
dc.contributor.authorLee, YS
dc.contributor.authorFortier, M
dc.contributor.authorGodfrey, KM
dc.contributor.authorEriksson, JG
dc.contributor.authorKarnani, N
dc.contributor.authorChan, S-Y
dc.date.accessioned2020-11-26T22:58:31Z
dc.date.available2020-11-26T22:58:31Z
dc.date.issued2021-01-01
dc.identifierpii: 10.1038/s41366-020-0596-5
dc.identifier.citationChu, A. H. Y., Tint, M. T., Chang, H. F., Wong, G., Yuan, W. L., Tull, D., Nijagal, B., Narayana, V. K., Meikle, P. J., Chang, K. T. E., Lewis, R. M., Chi, C., Yap, F. K. P., Tan, K. H., Shek, L. P., Chong, Y. -S., Gluckman, P. D., Lee, Y. S., Fortier, M. ,... Chan, S. -Y. (2021). High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort. INTERNATIONAL JOURNAL OF OBESITY, 45 (1), pp.247-257. https://doi.org/10.1038/s41366-020-0596-5.
dc.identifier.issn0307-0565
dc.identifier.urihttp://hdl.handle.net/11343/252062
dc.description.abstractBackground/Objectives Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. The placenta has been implicated in how maternal hyperglycaemia generates fetal pathophysiology, but no studies have examined whether placental inositol biology is altered with maternal hyperglycaemia, nor whether such alterations impact fetal physiology. We aimed to investigate whether the effects of maternal glycaemia on offspring birthweight and adiposity at birth differed across placental inositol levels. Methods Using longitudinal data from the Growing Up in Singapore Towards healthy Outcomes cohort, maternal fasting glucose (FPG) and 2-hour plasma glucose (2hPG) were obtained in pregnant women by a 75-g oral glucose tolerance test around 26 weeks’ gestation. Relative placental inositol was quantified by liquid chromatography-mass spectrometry. Primary outcomes were birthweight (n = 884) and abdominal adipose tissue (AAT) volumes measured by neonatal MRI scanning in a subset (n = 262) of term singleton pregnancies. Multiple linear regression analyses were performed. Results Placental inositol was lower in those with higher 2hPG, no exposure to tobacco smoke antenatally, with vaginal delivery and shorter gestation. Positive associations of FPG with birthweight (adjusted β [95% CI] 164.8 g [109.1, 220.5]) and AAT (17.3 ml [11.9, 22.6] per mmol glucose) were observed, with significant interactions between inositol tertiles and FPG in relation to these outcomes (p < 0.05). Stratification by inositol tertiles showed that each mmol/L increase in FPG was associated with increased birthweight and AAT volume among cases within the lowest (birthweight = 174.2 g [81.2, 267.2], AAT = 21.0 ml [13.1, 28.8]) and middle inositol tertiles (birthweight = 202.0 g [103.8, 300.1], AAT = 19.7 ml [9.7, 29.7]). However, no significant association was found among cases within the highest tertile (birthweight = 81.0 g [−21.2, 183.2], AAT = 0.8 ml [−8.4, 10.0]). Conclusions High placental inositol may protect the fetus from the pro-adipogenic effects of maternal glycaemia. Studies are warranted to investigate whether prenatal inositol supplementation can increase placental inositol and reduce fetal adiposity.
dc.languageEnglish
dc.publisherSPRINGERNATURE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleHigh placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort
dc.typeJournal Article
dc.identifier.doi10.1038/s41366-020-0596-5
melbourne.affiliation.departmentBio21
melbourne.source.titleInternational Journal of Obesity
melbourne.source.volume45
melbourne.source.issue1
melbourne.source.pages247-257
dc.rights.licenseCC BY
melbourne.elementsid1449628
melbourne.contributor.authorNijagal, Brunda
melbourne.contributor.authorMeikle, Peter
melbourne.contributor.authorTull, Dedreia
melbourne.contributor.authorNarayana, Vinod
dc.identifier.eissn1476-5497
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record