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dc.contributor.authorHan, LKM
dc.contributor.authorDinga, R
dc.contributor.authorHahn, T
dc.contributor.authorChing, CRK
dc.contributor.authorEyler, LT
dc.contributor.authorAftanas, L
dc.contributor.authorAghajani, M
dc.contributor.authorAleman, A
dc.contributor.authorBaune, BT
dc.contributor.authorBerger, K
dc.contributor.authorBrak, I
dc.contributor.authorFilho, GB
dc.contributor.authorCarballedo, A
dc.contributor.authorConnolly, CG
dc.contributor.authorCouvy-Duchesne, B
dc.contributor.authorCullen, KR
dc.contributor.authorDannlowski, U
dc.contributor.authorDavey, CG
dc.contributor.authorDima, D
dc.contributor.authorDuran, FLS
dc.contributor.authorEnneking, V
dc.contributor.authorFilimonova, E
dc.contributor.authorFrenzel, S
dc.contributor.authorFrodl, T
dc.contributor.authorFu, CHY
dc.contributor.authorGodlewska, BR
dc.contributor.authorGotlib, IH
dc.contributor.authorGrabe, HJ
dc.contributor.authorGroenewold, NA
dc.contributor.authorGrotegerd, D
dc.contributor.authorGruber, O
dc.contributor.authorHall, GB
dc.contributor.authorHarrison, BJ
dc.contributor.authorHatton, SN
dc.contributor.authorHermesdorf, M
dc.contributor.authorHickie, IB
dc.contributor.authorHo, TC
dc.contributor.authorHosten, N
dc.contributor.authorJansen, A
dc.contributor.authorKähler, C
dc.contributor.authorKircher, T
dc.contributor.authorKlimes-Dougan, B
dc.contributor.authorKrämer, B
dc.contributor.authorKrug, A
dc.contributor.authorLagopoulos, J
dc.contributor.authorLeenings, R
dc.contributor.authorMacMaster, FP
dc.contributor.authorMacQueen, G
dc.contributor.authorMcIntosh, A
dc.contributor.authorMcLellan, Q
dc.contributor.authorMcMahon, KL
dc.contributor.authorMedland, SE
dc.contributor.authorMueller, BA
dc.contributor.authorMwangi, B
dc.contributor.authorOsipov, E
dc.contributor.authorPortella, MJ
dc.contributor.authorPozzi, E
dc.contributor.authorReneman, L
dc.contributor.authorRepple, J
dc.contributor.authorRosa, PGP
dc.contributor.authorSacchet, MD
dc.contributor.authorSämann, PG
dc.contributor.authorSchnell, K
dc.contributor.authorSchrantee, A
dc.contributor.authorSimulionyte, E
dc.contributor.authorSoares, JC
dc.contributor.authorSommer, J
dc.contributor.authorStein, DJ
dc.contributor.authorSteinsträter, O
dc.contributor.authorStrike, LT
dc.contributor.authorThomopoulos, SI
dc.contributor.authorvan Tol, M-J
dc.contributor.authorVeer, IM
dc.contributor.authorVermeiren, RRJM
dc.contributor.authorWalter, H
dc.contributor.authorvan der Wee, NJA
dc.contributor.authorvan der Werff, SJA
dc.contributor.authorWhalley, H
dc.contributor.authorWinter, NR
dc.contributor.authorWittfeld, K
dc.contributor.authorWright, MJ
dc.contributor.authorWu, M-J
dc.contributor.authorVölzke, H
dc.contributor.authorYang, TT
dc.contributor.authorZannias, V
dc.contributor.authorde Zubicaray, GI
dc.contributor.authorZunta-Soares, GB
dc.contributor.authorAbé, C
dc.contributor.authorAlda, M
dc.contributor.authorAndreassen, OA
dc.contributor.authorBøen, E
dc.contributor.authorBonnin, CM
dc.contributor.authorCanales-Rodriguez, EJ
dc.contributor.authorCannon, D
dc.contributor.authorCaseras, X
dc.contributor.authorChaim-Avancini, TM
dc.contributor.authorElvsåshagen, T
dc.contributor.authorFavre, P
dc.contributor.authorFoley, SF
dc.contributor.authorFullerton, JM
dc.contributor.authorGoikolea, JM
dc.contributor.authorHaarman, BCM
dc.contributor.authorHajek, T
dc.contributor.authorHenry, C
dc.contributor.authorHouenou, J
dc.contributor.authorHowells, FM
dc.contributor.authorIngvar, M
dc.contributor.authorKuplicki, R
dc.contributor.authorLafer, B
dc.contributor.authorLandén, M
dc.contributor.authorMachado-Vieira, R
dc.contributor.authorMalt, UF
dc.contributor.authorMcDonald, C
dc.contributor.authorMitchell, PB
dc.contributor.authorNabulsi, L
dc.contributor.authorOtaduy, MCG
dc.contributor.authorOvers, BJ
dc.contributor.authorPolosan, M
dc.contributor.authorPomarol-Clotet, E
dc.contributor.authorRadua, J
dc.contributor.authorRive, MM
dc.contributor.authorRoberts, G
dc.contributor.authorRuhe, HG
dc.contributor.authorSalvador, R
dc.contributor.authorSarró, S
dc.contributor.authorSatterthwaite, TD
dc.contributor.authorSavitz, J
dc.contributor.authorSchene, AH
dc.contributor.authorSchofield, PR
dc.contributor.authorSerpa, MH
dc.contributor.authorSim, K
dc.contributor.authorSoeiro-de-Souza, MG
dc.contributor.authorSutherland, AN
dc.contributor.authorTemmingh, HS
dc.contributor.authorTimmons, GM
dc.contributor.authorUhlmann, A
dc.contributor.authorVieta, E
dc.contributor.authorWolf, DH
dc.contributor.authorZanetti, MV
dc.contributor.authorJahanshad, N
dc.contributor.authorThompson, PM
dc.contributor.authorVeltman, DJ
dc.contributor.authorPenninx, BWJH
dc.contributor.authorMarquand, AF
dc.contributor.authorCole, JH
dc.contributor.authorSchmaal, L
dc.date.accessioned2020-11-26T22:58:40Z
dc.date.available2020-11-26T22:58:40Z
dc.date.issued2021-09
dc.identifierpii: 10.1038/s41380-020-0754-0
dc.identifier.citationHan, L. K. M., Dinga, R., Hahn, T., Ching, C. R. K., Eyler, L. T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B. T., Berger, K., Brak, I., Filho, G. B., Carballedo, A., Connolly, C. G., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C. G., Dima, D. ,... Schmaal, L. (2021). Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.. Mol Psychiatry, 26 (9), pp.5124-5139. https://doi.org/10.1038/s41380-020-0754-0.
dc.identifier.issn1359-4184
dc.identifier.urihttp://hdl.handle.net/11343/252063
dc.description.abstractMajor depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleBrain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.
dc.typeJournal Article
dc.identifier.doi10.1038/s41380-020-0754-0
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleMolecular Psychiatry
melbourne.source.volume26
melbourne.source.issue9
melbourne.source.pages5124-5139
melbourne.identifier.nhmrc1064643
melbourne.identifier.nhmrc1024570
dc.rights.licenseCC BY
melbourne.elementsid1449714
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589647
melbourne.contributor.authorDavey, Christopher
melbourne.contributor.authorHarrison, Benjamin
melbourne.contributor.authorSchmaal, Lianne
melbourne.contributor.authorBaune, Bernhard
melbourne.contributor.authorPozzi, Elena
dc.identifier.eissn1476-5578
melbourne.identifier.fundernameidNHMRC, 1064643
melbourne.identifier.fundernameidNHMRC, 1024570
melbourne.identifier.fundernameidNATIONAL INSTITUTE OF HEALTH, R01MH117601 / 108606875
melbourne.accessrightsOpen Access


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