Risk Factors for Cardiovascular Events in Patients on Antidementia Medications.
AuthorHe, M; Stevenson, JM; Zhang, Y; Hernandez, I
Source TitleAmerican Journal of Alzheimer's Disease and Other Dementias
University of Melbourne Author/sZhang, Yuting
AffiliationMelbourne Institute of Applied Economic and Social Research
Document TypeJournal Article
CitationsHe, M., Stevenson, J. M., Zhang, Y. & Hernandez, I. (2020). Risk Factors for Cardiovascular Events in Patients on Antidementia Medications.. American Journal of Alzheimer's Disease and Other Dementias, 35, pp.1533317520922380-1533317520922380. https://doi.org/10.1177/1533317520922380.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315406
OBJECTIVE: To identify characteristics associated with an increased risk of cardiovascular events in patients diagnosed with Alzheimer disease (AD) and treated with antidementia medications. METHODS: Demographics, diagnoses, and medication usage of 30 433 Medicare patients were analyzed using 2006 to 2013 claims data and a combined model of screening, ranking and stepwise logistic regressions to evaluate factors associated with composite outcomes of 6 cardiovascular events. RESULTS: Incidence rate of at least 1 cardiovascular event was 25.1%. Fifty-five factors were identified from the 10 381 candidate variables by the combined model with a c-statistic of 67% and an accuracy of 75%. Factors associated with increased risk of cardiovascular events include history of heart rhythm disorders, alteration of consciousness (odds ratio [OR]: 1.25; 95% confidence interval [CI]: 1.14-1.36), and usage of β-blockers (OR: 1.19; 95% CI: 1.13-1.27). CONCLUSIONS: Clinicians should consider the increased risk of cardiovascular events in patients with AD with heart rhythm disorders and on β-blockers.
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