Show simple item record

dc.contributor.authorSinghal, G
dc.contributor.authorMorgan, J
dc.contributor.authorCorrigan, F
dc.contributor.authorToben, C
dc.contributor.authorJawahar, MC
dc.contributor.authorJaehne, EJ
dc.contributor.authorManavis, J
dc.contributor.authorHannan, AJ
dc.contributor.authorBaune, BT
dc.date.accessioned2020-11-26T22:59:06Z
dc.date.available2020-11-26T22:59:06Z
dc.date.issued2020-05-25
dc.identifierpii: 10.1007/s10571-020-00862-x
dc.identifier.citationSinghal, G., Morgan, J., Corrigan, F., Toben, C., Jawahar, M. C., Jaehne, E. J., Manavis, J., Hannan, A. J. & Baune, B. T. (2020). Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment. CELLULAR AND MOLECULAR NEUROBIOLOGY, 41 (3), pp.469-486. https://doi.org/10.1007/s10571-020-00862-x.
dc.identifier.issn0272-4340
dc.identifier.urihttp://hdl.handle.net/11343/252066
dc.description.abstractPhysical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, and PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort of 3-, 8-, and 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Control, PE, EE, or PE + EE groups and provided with either no treatment, a running wheel, a variety of plastic and wooden objects alone or in combination with a running wheel for seven weeks, respectively. Immunohistochemistry and 8-color flow cytometry were used to determine the numbers of dentate gyrus glial cells, and the proportions of CD4+ and CD8+ T cell numbers and their subsets from cervical lymph nodes, respectively. An increase in the number of IBA1+ microglia in the dentate gyrus at 5 and 10 months was observed after EE, while PE and PE + EE increased it only at 10 months. No change in astroglia number in comparison to controls were observed in any of the treatment groups. Also, all treatments induced significant differences in the proportion of specific T cell subsets, i.e., CD4+ and CD8+ T naïve (TN), central memory (TCM), and effector memory (TEM) cells. Our results suggest that in the short-term, EE is a stronger modulator of microglial and peripheral T cell subset numbers than PE and PE + EE, and the combination of short-term PE and EE has no additive effects.
dc.languageEnglish
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleShort-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment
dc.typeJournal Article
dc.identifier.doi10.1007/s10571-020-00862-x
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleCellular and Molecular Neurobiology
melbourne.source.volume41
melbourne.source.issue3
melbourne.source.pages469-486
dc.rights.licenseCC BY
melbourne.elementsid1450318
melbourne.contributor.authorBaune, Bernhard
melbourne.contributor.authorHannan, Anthony
dc.identifier.eissn1573-6830
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record